نتایج جستجو برای: structureactivity relationship
تعداد نتایج: 553387 فیلتر نتایج به سال:
The nuclear receptor member human pregnane X receptor (hPXR) regulates enzymes and transporters involved in xenobiotic detoxification as well as maintains homeostatic balance of bile acids, thyroid and steroid hormones. hPXR can be recognized and activated by a structurally diverse array of environmental chemicals and drug compounds to initiate adverse biological effects, such as perturbing nor...
the present study was an attempt to determine the types of motivation and levels of foreign language learning anxiety among efl students studying at azad and state universities in kermanshah and to determine the relationship between these two factors and language proficiency and gender. to this end, the foreign language learning motivation scale, by deci and ryan )1985(, were administered to 12...
INTRODUCTION 5-Fluorouracil and methotrexate are antimetabolites widely used in the treatment of neoplastic disease. They act by inactivating the two enzymes involved in the biosynthesis of the pyrimidine nucleotide 2’-deoxythymidine 5’-monophosphate, namely thymidylate synthase and dihydrofolate reductase. The three dimensional structure of each enzyme is known and the mechanisms of the reacti...
Rather different computational approaches are successfully employed to search for novel active compounds. Among those are various similarity-based methods that sometimes use only simple molecular representations. The complexity of computational tools and molecular representations does not correlate with their success in virtual screening and in recognizing increasingly diverse structures having...
In order to develop a better bioactive molecules with good efficacy, we synthesized a new series of Thiazolo [3,2-a] pyrimidine derivatives with good yield and studied their anthelmintic properties, structureactivity relationships (SARs). A new series of Thiazolo[3,2-a]pyrimidines have been synthesized through duff formylation, ‘One pot’ Biginelli reaction, cyclization followed by knoevenagel c...
monumental changes occurring on a daily basis have altered the world into a global village of expanding technology and shrinking geography in which preparing language learners for intercultural communication seems to be a sine qua non for modern language education. employing a cross-sectional design in its first phase, this study investigated the intercultural sensitivity and language proficien...
some researches made in the field of agency problem issue, deal with the role of control systems regarding owners and managers. in this research the relationship between the two control mechanisms, namely the voluntary disclosure (external control mechanism) and outside directors (internal control mechanism), which are reductive of agency problems, has been studied. for this reason, a sample ...
abstract this study examines the relationship between reading anxiety and difficulty of texts as well as the relationship between reading anxiety and students perceived difficulty of the texts. since difficulty is a relative concept, i limited its definition by sticking to the readability formula. we also took students perceived difficulty levels into account. therefore, in the present study, ...
the study reflected in this thesis aims at finding out relationships between critical thinking (ct), and the reading sections of tofel and ielts tests. the study tries to find any relationships between the ct ability of students and their performance on reading tests of tofel and academic ielts. however, no research has ever been conducted to investigate the relationship between ct and the read...
educational researchers have provided evidence that teachers’ emotional intelligence has strong effects on various aspects of teaching and learning. yet, in the field of teaching english to speakers of other languages (tesol), inquiry into teachers’ emotional intelligence is nearly limited. given its documented powerful impact on teaching practices and student learning, it is critical to pursue...
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