نتایج جستجو برای: structural dependent biological activity
تعداد نتایج: 2375451 فیلتر نتایج به سال:
Structurally modified derivatives of 7-deoxypancratistatin have been synthesized and evaluated in cancer cell line inhibition studies.
Studies on structure and function of polysaccharides in biological systems classically involve sequence and compositional analyses, anomeric configuration, type of glycosidic linkage, and presence of substituents. Recent studies, however, indicates that other structural parameters, so far little explored, can directly influence the biological activity of microbial polysaccharides. Among these p...
4 Ibid., 50, 664 (1963). 6 Geiduschek, E. P., G. P. Tocchini-Valentini, and M. Sarnat, these PROCEEDINGS, 52, 486 (1964). 6 Green, M., these PROCEEDINGS, 52, 1388 (1964). 7Luria, S. E., Biochem. Biophys. Res. Commun., 18, 735 (1965). 8 Chandler, B., M. Hayashi, M. N. Hayashi, and S. Spiegelman, Science, 143, 47 (1964). 6Jansz, H. S., and P. H. Pouwels, Biochem. Biophys. Res. Commun., 18, 589 (1...
Following the theoretical model by Hann et al. moderately complex structures are preferable lead compounds since they lead to specific binding events involving the complete ligand molecule. To make this concept usable in practice for library design, we studied several complexity measures on the biological activity of ligand molecules. We applied the historical IC50/EC50 summary data of 160 assa...
Indirubin is the crucial ingredient of Danggui Longhui Wan and Qing-Dai, traditional Chinese medicine herbal formulas used for therapy chronic myelocytic leukemia in China hundreds years. Although monomeric indirubin has been treatment human leukemia. However, due to low water solubility, poor pharmacokinetic properties therapeutic effects are major obstacle, had significantly limited its clini...
Introduction: Cervical cancer is the second prevalent cancer in developing countries and the sixth prevalent cancer in USA. Since conventional treatment methods are associated with detrimental side effects, searching for new drugs using natural ingredients is very important. Previous studies have shown that melittin (main component of honey bee venom) has anticancer properties along with the ef...
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