The orphan receptor tyrosine kinase Tie-1 is expressed in endothelial cells and is essential for vascular development. Nothing is known about the signaling pathways utilized by this receptor. In this study we have used chimeric receptors composed of the TrkA ectodomain fused to the transmembrane and intracellular domains of Tie-1, or the related receptor Tie-2, to examine Tie-1 signaling capaci...

Social network sites (SNSs) can create new marketing opportunities by leveraging on members’ online social networks. In particular, such sites can produce a new type of product endorser – “friend endorser”, whose effectiveness remains unknown as compared to other types of product endorsers. This paper investigated the impact of three critical factors on advertising effectiveness of different ty...

The rapid growth of Facebook has become an important channel of eWOM. Facebook users can openly illustrate their attitudes toward products to their friends, either by casually clicking a like or deliberately writing a comment on advertisements. This study explored how friends’ involvement in advertisements and tie strength affected Facebook users’ product attitudes, intentions to purchase, and ...

This paper examines the celebrated ‘Strength of weak ties’ theory of Granovetter (1973). We examine two hypotheses implied by the theory: one, for any three players with two links present, the probability of a third link being present is increasing in the strength of the two ties, and two, the removal of a weak tie breaks more shortest paths than the removal of a strong tie. This paper tests th...

OBJECTIVE To investigate the involvement of Tie-1 and Tie-2, receptor tyrosine kinases required for angiogenesis, in synovial proliferation and angiogenesis of rheumatoid arthritis (RA). METHODS Synovial tissues from 10 patients with RA and three control subjects were analysed by double immunohistochemistry and reverse transcriptase polymerase chain reaction (RT-PCR). RESULTS Expression of ...

abstractthis study focused mainly on the shifts of the grammatical cohesion in texts translated from english into persian. it aimed to identify the grammatical cohesive devices (gcds) in st and tt separately, based on halliday and hassn's model (1976), determine the number of occurrences of gcds in two texts and finally, illustrate types of shifts of grammatical cohesion and strategies used in ...

TIE is a receptor tyrosine kinase expressed in both mature endothelial cells and their precursors, as well as in some hematopoietic cells. Mouse embryos homozygous for a disrupted Tie allele die at midgestation due to impaired endothelial cell integrity and resulting hemorrhage. Here we have performed chimeric analysis to study further the function of the murine TIE in the development of embryo...

A receptor tyrosine kinase (RTK), TIE (tyrosine kinase that contains immunoglobulin-like loops and epidermal growth factor [EGF] homology domains), is expressed in vascular endothelial and hematopoietic cells. We generated monoclonal antibodies (MoAbs) against the extracellular domain of TIE and a polyclonal antibody against the TIE carboxyterminus and used them to analyze expression of TIE in ...

the effect of magnetic field on the liquid-liquid equilibrium of two ternary systems (water + acetic acid + butyl acetate and water + acetic acid + dimethyl succinate) at 298.15 k under atmospheric pressure was investigated. the results obtained show that the strength of the magnetic field (0.02 t) affects the solubility of acetic acid in the used organic solvents. distribution coefficients and...

This study examined which media people use on a day-to-day basis to communicate and whether tie strength influenced this use. Furthermore, we analyzed online offline interactions differ in perceived intimacy impacts interaction intimacy: 347 real of 9 participants (3 male, 6 female) were analyzed; 172 (WhatsApp, Facebook Messenger, email, SMS interactions) 175 (recorded phone face-to-face conve...