Solid tumors may modulate their environment and keep stromal cells in an immunosuppressive and tumor-promoting state. Recent findings indicate that targeting not only cancer cells but also nonmalignant stromal cells by T cells is required for the eradication of established tumor. Interestingly, a single adoptive transfer of effector T cells that recognize tumor antigen-loaded stromal cells, but...

Sclerosing stromal tumor of the ovary is a rare, benign ovarian tumor, seen primarily in young women. We report a 3-year-old girl who presented with a palpable lower abdominal mass. Computed Tomography (CT) study revealed a huge pelvic mass with an enhancement pattern typical of ovarian sclerosing stromal tumor. The diagnosis was confirmed by pathology examination of the surgically resected tum...