Dysregulation of excitatory and inhibitory signaling is commonly observed in major psychiatric disorders, including schizophrenia, depression, bipolar disorder, often targeted by psychological pharmacological treatment methods. The balance excitation inhibition highly sensitive to severe stress, one the strongest risk factors for disorders. role astrocytes regulating now widely recognized; howe...

Background & Aims of the Study: Worker’s behaviors, uncontrolled job stress, psycho- social factors and non-ergonomic principles, lead to risk of musculoskeletal disorders. This rsearch was done conducted to analyze relationship these factors in an auto-parts production company in Qom province, Iran in 2015. Materials and Methods: This study was a cross-sectional one condu...

Chronic or repeated stress, particularly psychosocial stress, is an acknowledged risk factor for numerous affective and somatic disorders in modern societies. Thus, there is substantial evidence showing that chronic stress can increase the likelihood of major depressive disorder and anxiety disorders, as well as cardiovascular diseases, irritable bowel syndrome and pain syndromes, to name but a...

background: the unified treatment approach (up), an emotion-focused cognitive-behavioral therapy that holds emotional processes as a central target of treatment, is applicable for disorders with strong emotional components. the aim of this study was to examine the effectiveness of emotion regulation intervention derivative from the up on emotional problems and quality of life among patients wit...

conclusions a large number (about two-thirds) of emts had some sort of back pain; it is highly recommended to promote the attitude and motivation of the individuals to take care to prevent back injury and inform them of the principles of back care. implications for primary prevention and care practice include encouraging emts to apply accurate principles of back care. results data showed that w...

Neurodegenerative disorders, such as Parkinson’s disease (PD), Alzheimer’s (AD), Amyotrophic lateral sclerosis (ALS), and Huntington’s (HD), are the most concerning disorders due to lack of effective therapy dramatic rise in affected cases. Although these have diverse clinical manifestations, they all share a common cellular stress response. These responses including neuroinflammation, oxidativ...