conclusions therefore, our results suggest that although administration of 300 mg/kg of calendula officinalis extract showed salutary effects on anti-oxidant profile, yet its protective effects on anti-diabetic and regenerative properties on nephropathy were ambiguous and require more investigations. background chronic hyperglycemia leads to microvascular and macrovascular complications such as...

OBJECTIVE To determine the effect of hyperglycemia and intraocular glucose delivery on ischemic retinal injury. METHODS Experimental diabetes was induced in age- and sex-matched Wistar rats by an injection of streptozocin. The functional and structural retinal injury in these rats after a period of pressure-induced retinal ischemia was compared with the injury in appropriate controls and with...

PURPOSE To evaluate the placental glycogen storage and fetal development in the pregnancy of neonatally streptozocin-induced diabetic rats and to establish relation with glycemia and insulin levels. METHODS At the birth day, 147 female rats were randomly distributed in two experimental groups: 1) Non-diabetic Group (Control, n=45) - received the vehicle; 2) Diabetic Group (STZ, n=102) - recei...

background and objective: lowering serum glucose and lipid levels in diabetic patients by using natural materials is of great importance. in this study, the effect of oral consumption of fumaria parviflora lamwas was assessed on serum glucose and lipid levels in streptozocin diabetic rats. materials and methods: in this experimental study, 32 male wistar rats were divided into four groups of co...

Objective: To evaluate the influence of combination of Grape seed extract and Zincovit tablets (nutritional food supplement) on blood glucose level in normal and streptozocin induced diabetic rats. Method: A total of 48 adult male Wistar rats (24 normal rats, 24 diabetic surviving rats) were divided into 8 groups of 6 rats each. Experimental hyperglycemia was produced in rats by single dose of ...

To examine the pattern and mechanism of enhanced intestinal nutrient absorption in diabetes, we measured intestinal transport of 3-0-methylglucose (30MG), I-alanine (ALA), and SO4 in male Lewis rats made diabetic with streptozocin. Diabetes enhanced 30MG absorption fivefold in ileum and threefold in jejunum; ALA absorption increased twofold in ileum but not at all in jejunum; ileal S04 transpor...

Nerve conduction impairment in experimental diabetes has been empirically but not mechanistically linked to altered nerve myo-inositol metabolism. The phospholipid-dependent membrane-bound sodium-potassium ATPase provides a potential mechanism to relate defects in diabetic peripheral nerve myo-inositol-phospholipid metabolism, impulse conduction, and energy utilization. Therefore, the effect of...

Metabolic memory (MM) is the phenomenon whereby diabetes complications persist and progress after glycemic recovery is achieved. Here, we present data showing that MM is heritable and that the transmission correlates with hyperglycemia-induced DNA hypomethylation and aberrant gene expression. Streptozocin was used to induce hyperglycemia in adult zebrafish, and then, following streptozocin with...

Glucose-induced insulin secretion by beta cells of diabetic db/db mice was studied by a pancreas perfusion technique, and the levels of GLUT2 protein in pancreatic islets were assessed by immunofluorescence microscopy and protein blot analysis. Beta cells from diabetic mice had a high basal rate of insulin secretion; they did not respond to glucose stimulation but displayed a normal secretory r...