Genetic and biochemical data have identified Smad4 as a key intracellular effector of the transforming growth factor beta (TGFbeta superfamily of secreted ligands. In mouse, Smad4-null embryos do not gastrulate, a phenotype consistent with loss of other TGFbeta-related signaling components. Chimeric analysis reveals a primary requirement for Smad4 in the extra-embryonic lineages; however, withi...

The establishment of the mammalian body plan depends on signal-regulated cell migration and adhesion, processes that are controlled by the Rho family of GTPases. Here we use a conditional allele of Rac1, the only Rac gene expressed early in development, to define its roles in the gastrulating mouse embryo. Embryos that lack Rac1 in the epiblast (Rac1Δepi) initiate development normally: the sign...

Xenopus Pitx1 is a homeobox gene whose family members are structurally and functionally conserved in organisms as diverse as Drosophila, chick, mouse, human, and frog. Present as a maternal transcript, the gene is zygotically expressed during gastrulation in a dorsal streak of cells. This streak restricts to a small circular domain underlying the center of presumptive neural plate. Shortly ther...

The transitional boundary layer flow over a flat plate is investigated. The boundary layer flow is known to develop unstable Tollmien-Schlichting waves above a critical value of the Reynolds number. However, it is also known that this transition can be observed for sub-critical Reynolds numbers. In that case the basin of attraction of the laminar state coexists with the sustained turbulence. In...

mhd boundary layer flow of two phase model nanofluid over a vertical plate is investigated both analytically and numerically. a system of governing nonlinear partial differential equations is converted into a set of nonlinear ordinary differential equations by suitable similarity transformations and then solved analytically using homotopy analysis method and numerically by the fourth order rung...

The experiment was carried out in Department of Plant Pathology, Dr Yashwant Singh Parmar University Horticulture and Forestry, Nauni, Solan, Himachal Pradesh, India during cropping season May to August year 2018–2019 study the efficacy fungal bacterial bio-control agents managing Fusarium wilt cucumber. Different were thus tested under laboratory conditions for their inhibiting mycelial growth...

The expression of the transcription factor gene Sox2 precisely marks the neural plate in various vertebrate species. We previously showed that the Sox2 expression prevailing in the neural plate of chicken embryos is actually regulated by the coordination of five phylogenetically conserved enhancers having discrete regional coverage, among which the 420-bp long enhancer N-1, active in the node-p...

BACKGROUND Longitudinal erythronychia (LE) is a term for red streaks in the nail. We describe the range of diseases manifested by localized (single or bifid) LE and explain the underlying physical changes. OBSERVATIONS Longitudinal erythronychia can be multiple or localized. Multiple lesions typically indicate an inflammatory disease such as lichen planus. When localized, they may be a single...