Specific delivery of therapeutic agents to solid tumors and their bioavailability at the target site are the most clinically important and challenging goals in cancer therapy. Liposomes are promising nanocarriers and have been well investigated for cancer therapy. In spite of preferred accumulation in tumors via the enhanced permeability and retention (EPR) effect, inefficient drug release at t...

background: we compared the wave amplitude of visually evoked potential (vep) between patients with esotropic and anisometropic amblyopic eyes and a normal group. methods: the wave amplitude of vep was documented in 2 groups of persons with amblyopia (15 with esotropia and 28 with anisometropia) and 1 group of individuals with normal visual acuity (n, 15). the amplitude of p100 was recorded mon...

Abstract Sensory stimuli can induce seizures in patients with epilepsy and predisposed subjects. Visual are the most common triggers, provoking through an abnormal response to light or pattern. Sensitive may intentionally provoke their visual stimuli. Self-induction methods widely described photo-sensitive patients, while there only a few reports of those who pattern-sensitive. We anal...

the aim of this randomized controlled clinical trial was to investigate the effect of a new iranian toothpaste and a commercially available toothpaste containing desensitizing agent (5% potassium nitrate) on dentine hypersensitivity in a 24-week study.fifty healthy volunteers, who had at least two sensitive root surfaces, completed the study period. the participants were randomly given one of t...

As the world’s second most abundant renewable natural phenolic polymer after cellulose, lignin is an extremely complex, amorphous, highly cross-linked class of aromatic polyphenolic macromolecules. Due to its special structure, considered be one suitable candidates replace fossil materials, thus research on functional materials has received extensive attention. Because stimuli-sensitive groups ...

The controlled delivery of active pharmaceutical ingredients to the site disease represents a major challenge in drug therapy. Particularly when drugs have be transported across biological barriers, suitable systems are importance. In recent years responsive been developed which enable release depending on internal or external stimuli such as changes pH, redox environment light and temperature....

the objective of the present study is to develop and investigate the swelling behavior of ph-sensitive superporous hydrogel (sph) and sph composite (sphc). a novel superporous hydrogel containing poly (methacrylic acid-co-acrylamide) was synthesized from methacrylic acid and acrylamide through the aqueous solution polymerization, using n,n-methylenebisacrylamide as a crosslinker and ammonium pe...

objective(s) in this study, a kind of ph sensitive composite membrane was prepared and drug permeation through it was investigated in terms of ph. rationale of this study originated from the fact that a ph change which may be a result of a disease state in the body can trigger drug release. materials and methods  here, a kind of ph sensitive composite membrane containing different nanoparticle ...