Specific and sensitive in vitro bioassays suitable for measurement of follicle-stimulating hormone (FSH) in small quantities of serum and urine have recently been validated. Comparisons of bioassay (B-FSH) potencies with immunoassay (I-FSH) estimates and chromatofocusing patterns have facilitated new discoveries regarding the regulation of FSH biosynthesis, storage, secretion, serum concentrati...

Peptides of the pro-opiocortin class produce pronounced cardiovascular and natriuretic actions. We have investigated the acute cardiovascular effects of one of the most potent members of this class, y2-melanocyte stimulating hormone (y2-MSH), in rats. Pressor actions of y2MSH administered systemicaMy were eliminated by ganglionic blockade with chlorisondamine. Peripheral cholinergic blockade fa...

The effect of graded exercise on the secretion of cortisol, testosterone, prolactin, growth hormone, thyroid stimulating hormone (TSH), luteinizing hormone and follicle stimulating hormone (FSH) is reported. While cortisol, prolactin, growth hormone and testosterone rise during the period of exercise, a rise in luteinizing hormone becomes evident only after rest. Levels of FSH and TSH remained ...

The interaction of highly purified pregnant mare serum gonadotropin (PMSG or eCG) has been studied in rat and equine testis homogenates. In the rat studies, unlabeled PMSG was shown to possess both high levels of intrinsic follitropin-like and lutropin-like activity when the inhibition of radioiodinated follitropin and lutropin binding by unlabeled PMSG was studied. Radioiodinated PMSG exhibite...

The CAMP-dependent protein kinase (EC 2.7.1.37; ATP:protein phosphotransferase) inhibitor in Sertoli cell-enriched rat testis has been shown to be specifically stimulated by follicle-stimulating hormone in uiuo. Intraperitoneal injection of follicle-stimulating hormone (100 pg of NIH-FSH-S12) induced a significant increase in protein kinase inhibitor 8 h after injection. Maximal stimulation of ...

OBJECTIVE To look for a relationship between the maternal age-specific incidence of complete molar pregnancy and the age-specific mid-follicular levels of circulating follicle stimulating hormone and luteinizing hormone. DESIGN Calculation of correlation coefficients between the incidence of complete mole and the circulating levels of follicle stimulating hormone and luteinizing hormone using...