When humans hop or run on different surfaces, they adjust their effective leg stiffness to offset changes in surface stiffness. As a result, the overall stiffness of the leg-surface series combination remains independent of surface stiffness. The purpose of this study was to determine whether humans make a similar adjustment when springs are placed in parallel with the leg via a lower limb orth...

BACKGROUND Pulse pressure and aortic pulse wave velocity, measures of arterial stiffness, are both important determinants of cardiovascular risk. However, assessment of peripheral pulse pressure does not always provide a reliable measure of changes in central pulse pressure or arterial stiffness. The aim of the present study was to assess the effect of acute changes in heart rate on arterial st...

Cells alter their mechanical properties in response to their local microenvironment; this plays a role in determining cell function and can even influence stem cell fate. Here, we identify a robust and unified relationship between cell stiffness and cell volume. As a cell spreads on a substrate, its volume decreases, while its stiffness concomitantly increases. We find that both cortical and cy...

We employ computer simulations and thermodynamic integration to analyze the effects of bending rigidity and slit confinement on the free energy cost of tying knots, ΔFknotting, on polymer chains under tension. A tension-dependent, nonzero optimal stiffness κmin exists, for which ΔFknotting is minimal. For a polymer chain with several stiffness domains, each containing a large amount of monomers...

this article presents the seismic vulnerability assessment of the s. joão de loure bridge, inportugal. the single span steel bridge has riveted joints, commonly affected by corrosion,which can lead to a significant stiffness reduction. with the objective of evaluating theinfluence of the joints stiffness in the structural response of the bridge, a structural model ofthe bridge was created, and ...

The ideal treatment for unstable thoracolumbar fractures remains controversial with posterior reduction and stabilization, anterior reduction and stabilization, combined posterior and anterior reduction and stabilization, and even nonoperative management advocated. Short segment posterior osteosynthesis of these fractures has less comorbidities compared with the other operative approaches but s...

background : previous studies have investigated different effects of muscle fatigue on body systems. however, there are no reports on the effect of fatigue protocol and its level on musculotendinous stiffness (mts) of the tricep-surae. this study was designed to compare the effects of 2 levels of submaximal fatigue contraction on mts of triceps-surae. methods: twenty female students by simple r...

Joint stiffness is a common complication of elbow trauma. Treating elbow stiffness is challenging, especially in patients with severe elbow stiffness with distal humeral nonunion. To improve treatment outcomes, the authors applied a hinged external fixator after performing open reduction and internal fixation and evaluated the clinical outcome. Between 2005 and 2011, eleven patients with elbow ...

When human hoppers are surprised by a change in surface stiffness, they adapt almost instantly by changing leg stiffness, implying that neural feedback is not necessary. The goal of this simulation study was first to investigate whether leg stiffness can change without neural control adjustment when landing on an unexpected hard or unexpected compliant (soft) surface, and second to determine wh...

The sudden stiffness reduction in a structure may cause the signal discontinuity in the acceleration responses close to the damage location at the damage time instant. To this end, the damage detection on sudden stiffness reduction of building structures has been actively investigated in this study. The signal discontinuity of the structural acceleration responses of an example building is extr...