One conundrum in Alzheimer’s disease (AD) research using transgenic mouse models is the high amount of successful memory-enhancing drugs. By contrast, very few drugs and of limited efficacy are available for humans having this pathology. As previously discussed (1), the advance in this field, i.e., to fulfill the translational facet of anti-AD research, requires deciphering why so many differen...

Treatment of heteroscorpionate ligand precursors pbptamH, pbpamH, sbpamH and (S)-mbpamH with 2 equivalents of AlR3 (R = Et, Me) yielded the corresponding binuclear organoaluminium complexes [Al2R4(μ-pbptam)] (R = Me 1, Et 2), [Al2R4(μ-pbpam)] (R = Me 3, Et 4), [Al2R4(μ-sbpam)] (R = Me 5, Et 6) and [Al2R4{μ-(S)-mbpam}] (R = Me 7, Et 8). These complexes have helical chirality due to the demands o...

Prototropy tautomerism and E/Z-stereoisomerism of 2-iminothiazolidin-4-ones was extensively studied in the literature during the past several decades. This tautomerism was studied for both alkyl/aryl–amino/imino-substituted thiazolidinones/ thiazolinones by several authors (Comrie, 1964; Åkerblom, 1967; Chowdry et al., 2000; Mornon & Raveau, 1971; Ramsh et al., 1978) in the solid state, as well...

ConspectusContradictory to the first intuitive impression that forging putatively flat aromatic rings evades stereoisomerism, a striking variety of atropisomeric compounds are conceivable by formation arenes, offering captivating avenues for catalyst-controlled stereoselective strategies. Since assembled products contain one or several rotationally restricted single bonds characterized especial...

As the gravity of glycoscience continues to amass, a commensurate demand for rapid, sensitive, and structurally comprehensive glycoanalytical tools has arisen. Among the most elusive but desirable analytical capabilities is the ability to expeditiously and unambiguously detect, distinguish, and resolve carbohydrates that differ only in their constitutional isomerism and/or stereoisomerism. Whil...

Out-of-plane deformations of metalloporphyrin skeletons have been well documented as playing important roles in relevant biological processes. In contrast, out-of-plane binding to the N-core large metal cations period 6 post-transition elements has remained poorly investigated. We describe herein monometallic complexes Pb(II) and Bi(III) with 5,10 single strapped porphyrin ligands bearing a car...