What is status epilepticus? For all the criticisms leveled at the now-traditional definition accepted by the International League Against Epilepsy (ILAE) and based on the 1962 Marseilles conference, “a condition characterized by an epileptic seizure which is so frequently repeated or so prolonged as to create a fixed and lasting epileptic condition” (1), this definition does capture the concept...

Nonconvulsive status epilepticus (NCSE) and epilepsia partialis continua (EPC) are common epileptic conditions for which straightforward recommendations based on controlled randomized trials for treatment in therapy refractory courses are lacking. In a large retrospective study on drug efficacy in status epilepticus (SE) we identified the patients treated in our department by searching for the ...

Status epilepticus (SE), an unremitting seizure, is known to cause a variety of traumatic responses including delayed neuronal death and later cognitive decline. Although excitotoxicity has been implicated in this delayed process, the cellular mechanisms are unclear. Because our previous brain slice studies have shown that chemically induced epileptiform activity can lead to elevated astrocytic...

Presidential Lecture: History of the American Clinical Neurophysiology Society’s Furthering of the Understanding of Status Epilepticus Frank W. Drislane, MD Soon after the founding of ACNS (1946), its leaders had made major advances in understanding status epilepticus (SE). First president, Herbert Jasper, helped elucidate the pathologic anatomy underlying seizures and studied EEG use. Gibbs an...

Status epilepticus is a life threatening neurological emergency. In persons with status epilepticus, if administration of a benzodiazepine and at least one antiepileptic drug has failed then management protocols for refractory status epilepticus should be put into effect. The article summarises the causes, effects, pathophysiology and treatment protocols for refractory status epilepticus.The co...

BACKGROUND AND OBJECTIVES In patients with epilepsy, a common comorbidity diagnosed is depression. Temporal lobe epilepsy or post status epilepticus (SE) animal model establish and validate the co morbidity and common pathogenesis of depression and epilepsy. Elevation in serotonin concentration gives an inhibitory response to epileptic discharge and stabilizes the depressed mood disorder. Piper...

objective this study was designed to determine the etiology of status epilepticus (se) andits relation to mortality. materials and methods this descriptive study was carried out based on the medical records of 40 patients with diagnosis of se discharged from pediatric hospital of bandar abbas between march 2002 and march 2004. multivariant analysis was pereformed to determine the prevalence of ...

This study aimed to determine the etiology, treatment protocol and outcome of convulsive status epilepticus (SE) in children. An institutional treatment protocol using benzodiazepines (diazepam and midazolam) was assessed in a retrospective case study. The treatment protocol (Ege Pediatric Status Epilepticus Protocol or EPSEP) was developed based on an operational definition of pediatric SE acc...

Status epilepticus (SE) is an acute and severe illness of the central nervous system, and prolonged SE can lead to brain damage and even death. Ketamine is a noncompetitive antagonist of glutamatergic N-methyl-d-aspartate (NMDA) receptors. During prolonged seizures, the numbers and activities of GABA receptors gradually decrease; thus, the commonly used first-line and second-line antiepileptic ...

objective absence status epilepticus (ase) is a common form of nonconvulsive status epilepcticus. it is  characterized by loss of consciousness with spike and wave discharges in eeg simultaneously. the most effective treatment of ase is diazepam, either infusion or in divided doses; the former is more expensive since patients must be admitted in an intensive care unit. the aim of this study was...