BACKGROUND The 2 × 2 factorial design is widely used for assessing the existence of interaction and the extent of generalizability of two factors where each factor had only two levels. Accordingly, research problems associated with the main effects and interaction effects can be analyzed with the selected linear contrasts. METHODS To correct for the potential heterogeneity of variance structu...

A novel, supersaturable self-microemulsifying drug delivery system (S-SMEDDS) was successfully formulated to enhance the dissolution and oral absorption of valsartan (VST), a poorly water-soluble drug, while reducing the total quantity for administration. Poloxamer 407 is a selectable, supersaturating agent for VST-containing SMEDDS composed of 10% Capmul® MCM, 45% Tween® 20, and 45% Transcutol...

In connection to sensory evaluations of foods, chemical or physical measurements of the relevant sensory properties are often searched for. The data available for testing whether some such instrumental measurement is linearly related to a sensory variable usually stem from a factorial experiment rather than from some random sub-population. Thus, to calibrate the two variables properly and to te...

OBJECTIVES Reassortment of influenza A viruses can give rise to viral ribonucleoproteins (vRNPs) with elevated polymerase activity and the previous three pandemic influenza viruses contained reassorted vRNPs of different origins. These suggest that reassorted vRNP may be one of the factors leading to a pandemic virus. In this study, we reconstituted chimeric vRNPs with three different viral str...

This paper reflects results of research into the use of factorial experimental design for rational constructing sensitivity and functionally oriented models for system optimization and control. The questions of overcoming difficulties of statistical evaluating the results of experiments with models of systems, but not real systems are discussed. The results of the paper are of a universal chara...