نتایج جستجو برای: statistical deficiencies
تعداد نتایج: 392628 فیلتر نتایج به سال:
Long-run tourism demand elasticities are important policy indicators for tourism product providers. Past tourism demand studies have mainly focused on the point estimates of demand elasticities. Although such estimates have some policymaking value, their information content is limited, as their associated sampling variability is unknown. Moreover, point estimates and their standard errors may b...
BACKGROUND Mitochondrial DNA (mtDNA) diseases are rare disorders whose prevalence is estimated around 1 in 5000. Patients are usually tested only for deletions and for common mutations of mtDNA which account for 5-40% of cases, depending on the study. However, the prevalence of rare mtDNA mutations is not known. METHODS We analysed the whole mtDNA in a cohort of 743 patients suspected of mani...
Clonally expanded mitochondrial DNA (mtDNA) deletions accumulate with age in human substantia nigra (SN) and high levels cause respiratory chain deficiency. In other human tissues, mtDNA point mutations clonally expand with age. Here, the abundance of mtDNA point mutations within single SN neurons from aged controls was investigated. From 31 single cytochrome c oxidase normal SN neurons, only o...
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