Introduction: Protein kinase M zeta (PKMζ) is assumed to be actively involved in retainig long-term potentiation. The goal of this study was to investigate the role of PKMζ in basolateral amygdala (BLA) upon acquisition, consolidation, retention and retrieval of memory using a specific inhibitor of PKMζ. Methods: Sixty male wistar rats underwent stereotaxic surgery and were cannu...

In the present study, we analyze the multi-channel service system with ordered entryfrom finite-source and finite-storage at each channel. The arrival and service rates are assumedto be state dependent. The steady state probabilities of the system are obtained by usingChapmann-Kolmogorov equations. Some other performance indices viz. utilization of servers,expected number of units in the system...

AIMS In the present study, the effects of bilateral intra-dorsal hippocampal (intra-CA1) injections of cholinergic agents on muscimol state-dependent memory were examined in mice. MAIN METHODS A single-trial step-down passive avoidance task was used for the assessment of memory retention in adult male NMRI mice. KEY FINDINGS Pre-training intra-CA1 administration of a GABA-A receptor agonist...

Recent accounts of memory suggest that retrieval of a learning experience transforms that memory into a labile state that requires a period of protein synthesis to be reconsolidated into a fixed state. In this article, we show that the impairments in behavior caused by the protein synthesis inhibitor anisomycin given after retrieval are temporary and are thus not likely to reflect disruptions i...

The present studies characterized the receptor mechanisms of morphine-induced states of memory. Morphine (5 mg/kg) produced a state in which rats could learn and retrieve an operant response; retrieval was impaired, however, when the rats were tested in the normal state. Conversely, rats that were trained in the normal state failed to retrieve the response in the morphine state. In either case ...