Each haemodialysis treatment requires the application of anticoagulation medicines, which will prevent coagulation in extracorporal blood circulation. In this study we try to determine the quality of admitted anticoagulant and his effect on lipid profile on hemodialysis patients after twelve months. We were applying standard heparin and low weight molecular heparin (LWMH). During our study we w...

Studies were performed to determine the cross-reaction rate of the heparin-dependent antibody with Org 10172, a new low molecular weight heparinoid, and to investigate the effect of Org 10172 on platelet activation induced by the antibody. The plasmas of 17 patients with thrombocytopenia induced by standard heparin were shown, by platelet aggregation studies, to contain the heparin-dependent an...

Long-term administration of heparin can lead to development of osteoporosis. The aim of the present study was to examine the effects of standard heparin and low-molecular-weight heparins (nadroparin, enoxaparin, parnaparin and dalteparin) on osteoclast formation from neonatal murine bone marrow cells stimulated by 1,25-dihydroxyvitamin D3 in vitro. Standard heparin (0.1-10 IU/ml) and low-molecu...

Background Heparin induced thrombocytopenia type II (HIT type II) is well defined thrombophylic and immunological complication due to heparin therapy, Witch occurs in 1-3% treated patients. In around 50% of the patients with HIT type II have developed serious thrombotic arterial and venous complications. It has a special place in cardiac surgery, regarding standard use of heparin. In patients w...

We report the simple synthesis and full investigation of a novel heparin binding dye, mallard blue, an arginine-functionalized thionine. This dye binds heparin in highly competitive media, including water with high levels of competitive electrolyte, buffered aqueous solution and human serum. The dye reports on heparin levels by a significant change in its UV-vis spectroscopic profile. Molecular...

J. Schrader, MD, Department of Nephrology, University Hospital, Robert-Koch-Strasse 40, D-3400 Göttingen (FRG) Dear Sir, We read with interest the recent report of Ponce et al. [1] in this journal on the interference of heparin with peritoneal solute transport. It has shown that intraperitoneal application of standard heparin does not affect or only slightly affects systemic blood coagulation [...

Heparin rebound phenomenon was named to illustrate unstable angina pectoris (UAP) reactivation after stopping heparin. Reinfarction clustering, as well as sharp increase of both thrombin production and activity in the early hours after heparin abandoning have been described (after thrombolysis), which has been partially attributed to heparin rebound. The aim of the study was to show importance ...

Background: Antibiotic-impregnated central venous catheters (CVCs) reduce the risk of bloodstream infections (BSIs) in patients treated in pediatric intensive care units (PICUs). However, it is unclear if they are cost-effective from the perspective of the National Health Service (NHS) in the UK. Methods: Economic evaluation alongside the CATCH trial (ISRCTN34884569) to estimate the incremental...

Using the chromogenic substrate S-2222, we have optimized and automated an amidolytic assay for heparin. The assay is based on the detection of anti-Xa activity generated by heparin in plasma. The method is reproducible (intra- and interassay CVs of 2.4 and 3.3%, respectively) and reliable in antithrombin III-deficient plasma. Results of this assay, obtained for plasma samples from patients and...