Perillyl alcohol (POH) is a monoterpene with anticarcinogenic and antitumor activity in murine tumor models. Putative mechanisms of action include activation of the transforming growth factor beta pathway and/or inhibition of p21ras signaling, leading to differentiation or apoptosis. In this Phase I trial, 17 patients took POH p.o. three times daily for 14 days of each 28-day cycle. The startin...

Aeolian dust is rarely considered an important source for nutrients in large peatlands, which generally develop in moist regions far from the major centers of dust production. As a result, past studies assumed that the Everglades provides a classic example of an originally oligotrophic, P-limited wetland that was subsequently degraded by anthropogenic activities. However, a multiproxy sedimenta...

Mailing Address: Jorge Humberto Guardado • Serviço de Cardiologia – Hospital Garcia de Orta 2800 Almada – Portugal E-mail: [email protected] Manuscript received May 28, 2006; revised manuscript received June 12, 2006; accepted June12, 2006.

Hyperspectral imaging can be used in assessing the quality of foods by decomposing the image into constituents such as protein, starch, and water. Observed data can be considered a mixture of underlying characteristic spectra (endmembers), and estimating the constituents and their abundances requires efficient algorithms for spectral unmixing. We present a Bayesian spectral unmixing algorithm e...