Activity of the serine-threonine protein kinase PINOID (PID) has been implicated in the asymmetrical localization of the membrane-associated PINFORMED (PIN) family of auxin transport facilitators. However, the means by which PID regulates PIN protein distribution is unknown. We have used recombinant PID protein to dissect the regulation of PID activity in vitro. We demonstrate that intramolecul...

This paper studies an enhanced dual-stage repetitive controller (RC) for improved robustness and tracking of periodic reference trajectories in piezo-based nanopositioning systems. The dual-stage RC system consists of a signal generator designed to provide high gain at the fundamental and all the harmonic frequencies of the reference trajectory and another that offers high gain only at the odd ...

Germline genetic mutations underlie various primary immunodeficiency (PID) diseases. Patients with rare PID diseases (like most non-PID patients and healthy individuals) carry, on average, 20,000 rare and common coding variants detected by high-throughput sequencing. It is thus a major challenge to select only a few candidate disease-causing variants for experimental testing. One of the tools c...

OBJECTIVE To study the microbial characteristics of patients with pelvic inflammatory disease (PID) and the possible impact of an intrauterine device (IUD) on the microbial environment in women presenting with PID. METHODS Case-control study, investigating 51 women with acute PID and 50 healthy women. Endocervical specimens for microbiological investigation were obtained at gynaecological exa...

The plant hormone auxin is a central regulator of plant development. In Arabidopsis, the PINOID (PID) protein serine/threonine kinase is a key component in the signaling of this phytohormone. To further investigate the biological function of PID, we performed a screen for PID-interacting proteins using the yeast two-hybrid system. Here, we show that PID interacts with two calcium-binding protei...

This paper describes the development and tuning methods for a novel self-organizing fuzzy proportional integral derivative (PID) controller. Before applying fuzzy logic, the PID gains are tuned using a conventional tuning method. At supervisory level, fuzzy logic readjusts the PID gains online. In the first tuning method, fuzzy logic at the supervisory level readjusts the three PID gains during...

BACKGROUND The 10 warning signs of primary immunodeficiency diseases (PID) have been promoted by various organizations in Europe and the United States to predict PID. However, the ability of these warning signs to identify children with PID has not been rigorously tested. OBJECTIVE The main goal of this study was to determine the effectiveness of these 10 warning signs in predicting defined P...

The presented paper deals with a new engineering method applicable to real plants with unknown mathematical model and varying parameters. Most of the existing 150 to 200 engineering PI(D) controller design methods are closely associated with the knowledge of the structure and parameters of the controlled plant [1], [2]. If neither the mathematical model of the controlled plant nor its parameter...

Objective Most women with Chlamydia trachomatis (CT) infection are asymptomatic, while ~3% progress to pelvic inflammatory disease (PID) within two weeks of untreated infection. The identification of biomarkers that predict development of PID would aid in identification of women at risk for complications of infertility and ectopic pregnancy. The specific aim of this study was to identify a whol...

The survival rate of lung cancer can be significantly improved by monitoring biomarkers in exhaled air that indicate diseases in early stage, so it is very important to develop micro analytical systems which can offer a fast, on-site, real-time detecting biomarkers in exhaled air. In this paper, a mini-gas chromatography (GC)-photo-ionization detector (PID) system integrated with a micro GC col...