A simple, specific, accurate, precise and stability-indicating reverse phase high performance liquid chromatography (RP-HPLC) method is developed for estimation of montelukast in tablet dosage form. The HPLC method, C-8 Column consisting of (25mm x 4.6mm x 5um – BDS) i.d in isocratic mode, with mobile phase containing 0.01M Potassium di-hydrogen orthophosphate buffer and acetonitrile in the rat...

A simple, rapid and precise method was developed for the quantitative estimation of prasugrel hydrochloride in pharmaceutical dosage form. A chromatographic separation of prasugrel and its degradants was achieved with Zorbax XDB C(8), 150 × 4.6 mm, 3.5μm analytical column using aqueous solution of 0.05 M ammonium acetate pH 4.5 with acetic acid-acetonitrile (40:60 v/v). The instrumental setting...

A simple, selective, precise, and stability-indicating high-performance thin-layer chromatographic (HPTLC) method for the analysis of ambroxol hydrochloride both as a bulk drug and in formulations was developed and validated. The method employed HPTLC aluminium plates precoated with silica gel 60F-254 as the stationary phase. The solvent system consisted of methanol-triethylamine (4:6 v/v). The...

A selective, specific and sensitive stability-indicating high-performance liquid chromatographic method was developed and validated for the determination of Tamsulosin in in pharmaceutical dosage forms. Celecoxib was used as Internal Standard (IS). The chromatographic conditions comprised of a reversed-phase Lichrocart / Lichrosphere C18 column (250 × 4.0 mm packed with 5) with mobile phase con...

A simple, selective, precise and stability-indicating high-performance liquid chromatographic (HPLC) method of analysis tolterodine tartrate in pharmaceutical dosage form was developed and validated. The chromatographic conditions comprised a reversed-phase C18 column (250 × 4.6 mm), 5 μ with a mobile phase consisting of a mixture of buffer solution (2.88 g ammonium dihydrogen orthophosphate in...

A simple, selective, precise and stability indicating high-performance liquid chromatographic method was developed and validated for the determination of pimozide in bulk and pharmaceutical dosage form. The method employed aluminium plates precoated with silica gel 60F-254 as the stationary phase. The solvent system consisted of toluene:acetone:ammonia (5:5:0.1 v/v/v). Compact spot was observed...