نتایج جستجو برای: squamous cell of head and neck

تعداد نتایج: 24184044  

Journal: :Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2005
Jordi Giralt Jacques Bernier

Journal: :Head & neck 2013
Jill Gilbert Ju Whei Lee Athanassios Argiris Missak Haigentz Lawrence Eric Feldman Minyoung Jang Pattatheyil Arun Carter Van Waes Arlene A Forastiere

BACKGROUND Constitutive activation of nuclear factor κB (NF-κB) is associated with poor prognosis. Irinotecan demonstrates single-agent activity in head and neck cancer but activates NF-κB, promoting cell survival and resistance. Bortezomib is a proteasome inhibitor that inactivates NF-κB. PATIENTS AND METHODS We performed a randomized phase II trial of bortezomib on days 1, 4, 8, and 11 and ...

Journal: :Head & neck 2010
J Chad Brenner Martin P Graham Bhavna Kumar Lindsay M Saunders Robbi Kupfer Robert H Lyons Carol R Bradford Thomas E Carey

BACKGROUND We established multiple University of Michigan Squamous Cell Carcinoma (UM-SCC) cell lines. With time, these have been distributed to other labs all over the world. Recent scientific discussions have noted the need to confirm the origin and identity of cell lines in grant proposals and journal articles. We genotyped the UM-SCC cell lines in our collection to confirm their unique iden...

2012
Daniel E. Johnson

Head and neck squamous cell carcinomas (HNSCC) are common human malignancies with poor clinical outcomes. The 5-year survival rates for patients with advanced stage HNSCC have not changed appreciably in the past few decades, underscoring a dire need for improved therapeutic options. Recent studies have elucidated a key signaling axis, the EGFR-STAT3-Bcl-XL signaling axis, that is aberrantly act...

Journal: :iranian journal of cancer prevention 0
rajan paliwal dept. of radiatiation oncology, acharya tulsi regional cancer treatment and research institute, bikaner, rajasthan university of health sciences, jaipur, rajasthan, india arvind kumar patidar dept. of radiatiation oncology, acharya tulsi regional cancer treatment and research institute, bikaner, rajasthan university of health sciences, jaipur, rajasthan, india rahul walke dept. of radiatiation oncology, acharya tulsi regional cancer treatment and research institute, bikaner, rajasthan university of health sciences, jaipur, rajasthan, india pushpendra hirapara dept. of radiatiation oncology, acharya tulsi regional cancer treatment and research institute, bikaner, rajasthan university of health sciences, jaipur, rajasthan, india sandeep jain dept. of radiatiation oncology, acharya tulsi regional cancer treatment and research institute, bikaner, rajasthan university of health sciences, jaipur, rajasthan, india megh raj bardia dept. of radiatiation oncology, acharya tulsi regional cancer treatment and research institute, bikaner, rajasthan university of health sciences, jaipur, rajasthan, india

background: the locally advanced head and neck cancer with fixed nodes are incurable and has a short survival. this study aims to evaluate the symptom relief, disease response and acute toxicity after palliative hypofractionated radiotherapy. methods: between december 2010 to june 2011, previously untreated 50 patients who had histopathologically proved of head and neck squamous cell carcinoma ...

Journal: :Ai zheng = Aizheng = Chinese journal of cancer 2009
Zu-Ping Zhang Yu-Lan Sun Li Fu Feng Gu Lun Zhang Xi-Shan Hao

BACKGROUND AND OBJECTIVE Notch1 belongs to the Notch family of transmembrane receptors and plays an important role in tumor cell proliferation and apoptosis. Notch1 affects chemosensitivity of tumors. However, its correlation to cisplatin (DDP)-sensitivity of head and neck squamous cell carcinoma is unclear. This study was to identify the expression of Notch1 in head and neck squamous cell carc...

Journal: :iranian journal of immunology 0
mete eyigor akdeniz university medical faculty, department of medical microbiology hulya eyigor department of ent head and neck surgery, antalya education and research hospital ustun osma department of ent head and neck surgery, antalya education and research hospital mustafadeniz yilmaz department of ent head and neck surgery, antalya education and research hospital nuray erin akdeniz university medical faculty, department of medical pharmacology omer tarik selcuk department of ent head and neck surgery, antalya education and research hospital cem sezer

background: although the imbalance of cytokines in head and neck squamous cell carcinoma (hnscc) is well known, there is scarce data regarding its occurrence during dysplasia, before the malignant transformation. objective: to determine whether laryngeal dysplasia patients show a different cytokine profile than patients with cancer and healthy controls. methods: seventeen newly diagnosed, untre...

Journal: :Cancers 2015
Andrew C Birkeland Megan L Ludwig Taha S Meraj J Chad Brenner Mark E Prince

Recent genomic sequencing studies have provided valuable insight into genetic aberrations in head and neck squamous cell carcinoma. Despite these great advances, certain hurdles exist in translating genomic findings to clinical care. Further correlation of genetic findings to clinical outcomes, additional analyses of subgroups of head and neck cancers and follow-up investigation into genetic he...

2015
Takumi Kumai Takayuki Ohkuri Toshihiro Nagato Yoshinari Matsuda Kensuke Oikawa Naoko Aoki Shoji Kimura Esteban Celis Yasuaki Harabuchi Hiroya Kobayashi

HER-3 expression has been reported to act as an important oncoprotein in head and neck squamous cell carcinoma. This protein is known to control tumor proliferation and acquisition of resistance by tumor cells towards EGFR inhibitors, therefore, development of a HER-3-targeted therapy is desirable. In this study, we found that HER-3 expression on tumor cells was increased after EGFR inhibition....

Journal: :middle east journal of cancer 0
rahul gandhi department of oral medicine and radiology, saraswati-dhanwantari dental college and hospital and post-graduate research institute, parbhani, maharashtra, india abhishek singh nayyar department of oral medicine and radiology, saraswati-dhanwantari dental college and hospital and post-graduate research institute, parbhani, maharashtra, india rahul bhowate department of oral medicine and radiology, sharad pawar dental college and hospital, wardha, maharashtra, india sweta gandhi department of public health dentistry, lata mangeshkar dental college and hospital, nagpur, maharashtra, india girish dongerwar department of oral medicine and radiology, saraswati-dhanwantari dental college and hospital and post-graduate research institute, parbhani, maharashtra, india

background: although color doppler ultrasonography (cdus) is useful in the diagnosis of various diseases of the head and neck, flow signals in oral malignant masses are less studied; hence the present study assesses the usefulness of color doppler ultrasonography in quantifying oral squamous cell carcinoma (oscc) vascularization. in addition, we determine the hemodynamic parameters by spectral ...

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