An extensive safety database has been developed for the chlorotriazine herbicide, atrazine. The results from five oncogenicity studies conducted in the Sprague-Dawley rat, two studies in the Fischer 344 rat, and two studies in the CD-1 mouse were reviewed. No increase in the incidence of tumors of any type was observed in male or female Fischer 344 rats, male or female CD-1 mice, or male Spragu...

Diana L. Miglioretti, PhD; Michael C. S. Bissell, Karla Kerlikowske, MD; M. Buist, Steven R. Cummings, Louise Henderson, Tracy Onega, Ellen O’Meara, Garth H. Rauscher, Brian Sprague, Anna N. A. Tosteson, ScD; Karen J. Wernli, Janie Lee, Christoph I. MD, MS

Background : Immunotherapy is widely used to increase the response rate of chemotherapy drugs. Eleuhterine palmifolia (L) Merr or dayak onion are known contain phytochemical compounds that have antiproliferative effects, and been as anti-cancer empirical therapies. This study aimed prove effect extract in Sprague-Dawley rats with breast cancer.
 Methods 18 Sprague-dawley rats, divided into...

Macroscopic and microscopic characteristics of 210 spontaneous ovarian tumors from 7748 Sprague-Dawley rats are described. The tumors were classified as tubular adenoma, anaplastic adenocarcinoma, papillary cystadenoma, papillary cystadenocarcinoma, mesothelioma, sertoliform tubular adenoma, Sertoli's cell tumor, granulosa cell tumor, thecal cell tumor, polycystic sex cord/stromal tumor, and li...

We investigated intrauterine growth restriction, endothelial function, and uterine artery blood flow characteristics in a transgenic preeclampsia rat model with an activated renin-angiotensin system. We compared preeclamptic Sprague-Dawley (SD-PE) rats with normal pregnant Sprague-Dawley and nonpregnant Sprague-Dawley rats. We used transabdominal ultrasound and found that SD-PE rat embryos deve...

The proton-coupled amino acid transporter, PAT1, is known to be responsible for intestinal absorption drug substances such as gaboxadol and vigabatrin. aim of the present study was investigate, if 17-α-ethinyl-estradiol (E-E2) 17-β-estradiol (E) inhibit PAT1-mediated proline taurine in vitro Caco-2 cells vivo using Sprague-Dawley rats assess potential taurine-drug interactions. E E-E2 inhibited...

Time-related changes in the incidences of spontaneous neoplasms in skin (fibroma and keratoacanthoma), thyroid (C-cell and follicular cell adenomas/carcinomas), uterus (stromal polyp), testes (Leydig cell tumor) and hemolymphoreticular system (mesenteric lymph node hemangioma and malignant granular lymphocytic leukemia) were assessed statistically in Wistar, Sprague-Dawley and F344 rats employe...

The aim of this study was to determine whether the time of day ceftriaxone was administered modified its pharmacokinetics. Ceftriaxone was given intraperitoneally at either 0400, 1000, 1600, and 2200 h to Sprague-Dawley rats synchronized under a light-dark cycle of 12 h of light and 12 h of dark. Pharmacokinetic parameters were analyzed for the presence of a 24-h rhythm. Results showed signific...

We present two new results on Wythoff’s Grundy function G. The first one is a proof that for every integer g 0, the g-values of G are within a bounded distance to their corresponding 0-values. Since the 0-values are located roughly along two diagonals, of slopes and , the g-values are contained within two strips of bounded width around those diagonals. This is a generalization of a previous res...