dowling-degos disease is a rare sporadic or autosomal dominant pigmentary entity, in which clusters of papules and reticulate macules slowly develop with predominance in flexural regions. this entity is due to mutations in the keratin 5 gene, and is related with other cutaneous disorders. we report the sporadic form of dowling-degos disease in an elderly man with multiple seborrheickeratosis in...

The most popular animal models of Alzheimer’s disease (AD) are transgenic mice expressing human genes with known mutations which do not represent the most abundant sporadic form of the disease. An increasing number of genetic, vascular and psychosocial data strongly support that the Octodon degus, a moderate-sized and diurnal precocial rodent, provides a naturalistic model for the study of the ...

sporadic alzheimer’s disease (sad) is affected by genetic risk factors, aging and oxidative stresses. the herbal extract of r. canina, t. vulgare and u. dioica has a beneficial role in aging, as an anti-inflammatory and anti-oxidative agent. we investigate the neuroprotective effects of this herbal extract in the rat model of sad.  the rats were divided into control, sham, model, herbal extract...