Madurai, (India) ABSTRACT In this paper we explore the finite automaton for n-cut splicing system. We propound a group structure for the automaton of splicing system. In addition, the product of automaton of splicing system with itself is scrutinized. It is found that the reconstructed machine from the product of automaton of splicing system is isomorphic to the automaton of splicing system. He...

Abstract It is clearly established that the immune system can affect cancer response to therapy. However, influence of tumor microenvironment (TME) on cells not completely understood. In this respect, alternative splicing increasingly described system. Here, we showed TME, via a TGFβ-dependent mechanism, increased events and induced expression an isoform IRF1 transcription factor (IRF1Δ7) in Th...

Alternative splicing in mammalian cells has been suggested to be largely controlled by combinatorial binding of basal splicing factors to pre-mRNA templates. This model predicts that distinct sets of pre-mRNA splicing factors are associated with alternatively spliced transcripts. However, no experimental evidence for differential recruitment of splicing factors to transcripts with distinct spli...

In the manufacturing industries, main problem of material handling process using conveyor belt. Belt that continuously work will have damage or failure, so it repair by cold splicing. The purpose this study is to see effect splicing parameters on shear strength belt joints based variations in number belts, bias cut and adhesive thickness. Variations ply belts used are 2 ply, 3 4 0.3xB, 0.6xB 0....

Alternative splicing generates protein diversity and allows for post-transcriptional gene regulation. Estimates suggest that 10% of the genes in Caenorhabditis elegans undergo alternative splicing. We constructed a splicing-sensitive microarray to detect alternative splicing for 352 cassette exons and tested for changes in alternative splicing of these genes during development. We found that th...

Splicing systems are generative mechanisms based on the splicing operation introduced by Tom Head as a model of DNA recombination. We prove that the generative power of finite extended splicing systems equals that of Turing machines, provided we consider multisets or provided a control mechanism is added. We also show that there exist universal splicing systems with the properties above, i. e. ...

Transcription and splicing are intrinsically linked, as splicing needs a pre-mRNA substrate to commence. The more nuanced view is that the rate of transcription contributes to splicing regulation. On the other hand there is accumulating evidence that splicing has an active role in controlling transcription elongation by DNA-dependent RNA polymerase II (RNAP II). We briefly review those mechanis...

Dysregulation of splicing factor expression and altered alternative splicing are associated with aging in humans and other species, and also with replicative senescence in cultured cells. Here, we assess whether expression changes of key splicing regulator genes and consequent effects on alternative splicing are also associated with strain longevity in old and young mice, across 6 different mou...

Alternative splicing of fibroblast growth factor receptor-2 (FGFR2) mutually exclusive exons IIIb and IIIc results in highly cell-type-specific expression of functionally distinct receptors, FGFR2-IIIb and FGFR2-IIIc. We previously identified an RNA cis-element, ISE/ISS-3, that enhanced exon IIIb splicing and silenced exon IIIc splicing. Here, we have performed comprehensive mutational analysis...

Splicing is a binary operation on strings defined by T. Head in 1987 which is inspired by the cut and paste phenomenon on DNA molecules [2]. Based on this operation, splicing systems, or H systems, were proposed as a generative device of languages: starting from a set of words, by repeated application of the splicing operation, new words may be generated. When we consider Păun’s definition, two...