An 87-year-old man who had been under urological follow-up with a raised prostate-specific antigen was referred to haematology widespread infiltrative bone disease, sternal and vertebral fractures normocytic anaemia. He two-year history of pain, which worsened in the previous two months. Serum protein electrophoresis revealed an immunoglobulin (Ig) A lambda paraprotein at too low concentration ...

Spindle cell lipoma is a rare lipoma, originates from subcutaneous tissue and mostly seen at back region. In this case report we represent a case with inguinal mass misdiagnosed as inguinal hernia and then diagnosed as spindle cell lipoma. There are two cases in literature with spindle cell lipoma originating from spermatic cord. This case is unique as having both pheochromacytoma and inguinal ...

Cell division in all eukaryotes depends on function of the spindle, a microtubule-based structure that segregates chromosomes to generate daughter cells in mitosis or haploid gametes in meiosis. Spindle size adapts to changes in cell size and shape, which vary dramatically across species and within a multicellular organism, but the nature of scaling events and their underlying mechanisms are po...

The cytoplasmic dynein motor generates pulling forces to center and orient the mitotic spindle within the cell. During this positioning process, dynein oscillates from one pole of the cell cortex to the other but only accumulates at the pole farthest from the spindle. Here, we show that dynein light chain 1 (DYNLL1) is required for this asymmetric cortical localization of dynein and has a speci...