objective(s) recent studies revealed the neuroprotective effects of epigallocatechin gallate (egcg) on a variety of neural injury .the purpose of this study was to determine the effects of egcg on the tissue lipid peroxidation after spinal cord injury (sci). materials and methods rats were randomly divided into four groups of 7 rats each as follows: sham-operated group, trauma group, and egcg-t...

pediatric neurological disorders including muscular dystrophy, cerebral palsy, and spinal cord injury are defined as a heterogenous group of diseases, of which some are known to be genetic. the two significant features represented for stem cells, leading to distinguish them from other cell types are addressed as below: they can renew themselves besides the ability to differentiate into cells wi...

background & aim: spinal cord injury (sci) has a very long history, and its cases form a large proportion of patients admitted to trauma centers in iran. studies show that repair after spinal cord injury can be done. in fact, many pharmaceutical agents, such as erythropoietin (epo), are applied to reduce secondary injury following the initial disorder and to maintain the nerve tissue. methods &...

many experimental studies have reported behavioral improvement after transplantation of peripheral nerve tissue into the contused spinal cord, even in large animals. the safety of this treatment in human remains unknown. in this translational phase 1 study, safety of peripheral nerve grafting for chronic spinal cord injuries and possible outcomes are being reported. twelve complete motor spinal...

the first necessary step in researches to treat spinal cord injuries (sci) is to understand complexities related to the neurophysiology and neurobiology changes of human sci with stem cell therapy(sct). the aim of this study is to identify these changes. the level of injuries is important in treatment and determination of this injury (whether it is complete, incomplete, or discomplete) is valua...

prevalence of spinal cord injury (sci) in iran is considerable and developing a national registry is substantial. registry can be a foundation of efforts for patient care improvement, clinical research facilitation, preventative strategy formulation and policymaking for better support of patients. with respect to long-term and multiple consequents of the lesions that will have a negative impact...

objective: an assessment of  nonoperative and operative intervention in regards  to  neurological  improvement  following  traumatic  closed  cervical spinal cord injury (csci). method: a retrospective evaluation of a cohort of patients with a csci from c3 to t1 was reviewed. the analysis included a total of 13 eligible patients. the  neurologic  and  functional outcomes  were  recorded  from  ...

spinal cord injury (sci) leads to loss of nervous tissue and consequently to catastrophic neurological deficits. up to now there is no definite treatment available that restores the loss of function to a degree that an independent life can be guaranteed.this justifies the cost of research into the new modalities for a treatment of scis. in current paper, recent developments and new approaches i...

objectives: nowadays, spinal cord lesions, specially its injury, is one of the diseases/injuries that human-being is been affected by. it not only causes irreversible economical/social/cultural problems & uncompensated costs to the patient’s family & society but also, makes active peoples to inactive & needy ones. till now, there is no successful treatment for these patients so this ailment, it...

Neurological outcomes following spinal cord injury (SCI) are currently difficult to predict. While the initial American Spinal Injury Association Impairment Scale (AIS) grade can give an estimate o...