The National Spinal Cord Injury Database has been in existence since 1973 and captures data from an estimated 13% of new SCI cases in the U.S. Since its inception, 28 federally funded SCI Model Systems have contributed data to the National SCI Database. As of December 2011, the database contained information on 28,450 persons who sustained traumatic spinal cord injuries. All the remaining stati...

The Department of Veterans Affairs (VA) provides services to more than 25,000 veterans with spinal cord injuries and disorders (SCI/D). This article introduces researchers to the use of VA data to examine questions related to SCI/D using examples from Spinal Cord Injury Quality Enhancement Research Initiative studies. Sources of VA data available to investigators interested in SCI/D research in...

Compression injuries of the murine spinal cord are valuable animal models for the study of spinal cord injury (SCI) and spinal regenerative therapy. The calibrated forceps model of compression injury is a convenient, low cost, and very reproducible animal model for SCI. We used a pair of modified forceps in accordance with the method published by Plemel et al. (2008) to laterally compress the s...

background :cell-based therapies can be used to treat neurological diseases and spinal cord injuries. the aim of this study was to assess the clinical outcome of bone marrow derived mononuclear cells (bm-mncs) transplantation in patients with spinal cord injuries.   method s: following a systematic review to detect clinical intervention studies, a meta-analysis was done for pooling data to esti...

While paralysis is widely appreciated to impact the quality-of-life after spinal cord injuries (SCIs), neuropathic chronic pain may also occur in many cases. In this study, we investigated whether human umbilical cord-derived mesenchymal stromal cells (hUCMSCs) possess the therapeutic potential to reduce neuropathic pain following SCI in rats. Spinal cord hemitransection, which was used as a ra...

Each year, there are an estimated 12 000 individuals who sustain a spinal cord injury (SCI) in the United States. Improved understanding of the pathophysiology of SCI and its sequelae has over the past 50 years led to the development of medical treatments (especially urologic) that have enhanced short- and long-term survival from these injuries. The prevalence of individuals with SCI in this co...

introduction spinal cord injury without radiological abnormality (sciwora) is a rare entity and usually involves the cervical spine. thoracic spine involvement is very rare due to the stability provided by the rib cage. the mechanisms of injury and pathophysiology are still debatable. case presentation we present a case of an adult male who had road traffic accident and presented with paraplegi...

Worldwide, spinal cord injury (SCI) affects around 500,000 people each year and results in significant morbidity. The primary insult to the occurs at time of initial injury, which may result from a contusion, laceration or more rarely transection. Secondary damage SCI is insidious subacute; it combination an inflammatory response, vascular changes ionic dysregulation. Early clinical interventio...

The purpose of this study is to measure the outcome of a comprehensive learning management system implemented at a Spinal Cord Injury (SCI) hospital in the Southeast United States. Specifically this SCI hospital has been experiencing an evident volume of patients returning seeking more information about the nature of their injuries. Recognizing the need to disseminate SCI information, the hospi...