BACKGROUND We investigated the molecular mechanism of ß-lactam resistance in extended-spectrum ß-lactamase (ESBL)-producing Enterobacterial strains isolated in neonatal units of different hospitals in Anatnanarivo, Madagascar. METHODS Bacteria were identified by standard biochemical methods, disc diffusion antibiograms and Etest. Resistance genes were sought by PCR. Strains were characterized...

U rsel S tuh lem m er, W ern er H aussm ann , F ran k M ilek , W olfgang K reis, and E rn s t R e in h a rd Pharmazeutisches Institut, Eberhard-Karls-Universität, A uf der Morgenstelle 8 D-72076 Tübingen, Bundesrepublik Deutschland Z. Naturforsch. 48 c, 713-721 (1993); received July 23,1993 Digitalis lanata, Biotransformation, Cardenolide Biosynthesis, Cell-Free System, 3 a-Hydroxysteroid-5 ß-o...

In the fetal lung, endogenous transforming growth factor-ß (TGF-ß) inhibits early morphogenesis and blocks hormone-induced type II cell differentiation. We hypothesized that endogenous TGF-ß inhibits type II cell differentiation and that the stimulatory effects of glucocorticoids result in part from suppression of TGF-ß. Epithelial cells were isolated from human fetal lung and cultured under de...

Further investigation of polar constituents in white lupin roots revealed the presence of genistein 7-O-ß-glucoside (la), genistein 4'-0-ß-glucoside (lb), 2'-hydroxygenistein 7-0ß-glucoside (2a) and 2'-hydroxygenistein 4'-0-ß-glucoside (2b) as simple isoflavone gluco­ sides; luteone 7-O-ß-glucoside (3 a), licoisoflavone A 7-O-ß-glucoside (4 a) and licoisoflavone A 4'-0-ß-glucoside (4b) as preny...

Erythromelalgia is the main, pathognomonic and presenting symptom in patients with Essential Thrombocythemia and thrombocythemia associated with Polycythemia Vera. Complete relief of erythromelalgic and acrocyanotic pain is obtained with the cyclooxygenase inhibitors aspirin and indomethacin, but not with sodiumsalicylate, dipyridamol, sulfinpyrozone and ticlopedine indicating that platelet-med...

Abstract Introduction Sleep disorders constitute a major public health burden yet remain widely undiagnosed and untreated. The prevalence of diagnosed sleep associations with objectively measured sleep-wake dysfunction vary across populations. Here, we examined the self-reported objective architectural correlates four in large sample individuals using consumer technology. Methods Data from 33,4...

Two isomeric partially acetylated galactocerebrosides, ß-D-galactopyranosyl (2,3,4-tri-O-acetyl)and ß-Dgalactopyranosyl (2,4,6-tri-O-acetyl)-1’(3’-O-acetyl)ceramide, were prepared from galactocerebroside and sulfatide, respectively. Their galactofuranosylation produced ß-D-galactofuranosyl-6and ß-D-galactofuranosyl-3-ß-Dgalactopyranosyl-1’ceramide, as demonstrated by 1 H and 13 C NMR spectra as...