Cimetidine was administered by stomach tube to rats at 70 or 700 mg/kg, doses corresponding to 5 or 50 times, respec tively, the typical daily dose of individuals on cimetidine treat ment. In some cases, cimetidine (70 mg/kg) was administered in combination with a 2-fold molar excess of sodium nitrite. This treatment was carried out up to 6 times over a 3-day period, the pH of the rat stomach b...

Our goal in writ ing “Dam aged Mer chan dise?” (DM) was not to have the last word on the sub ject but to raise an aware ness within the hu man–com puter in ter ac tion (HCI) com mu nity of is sues that we felt had been too long ig nored or ne glected. On read ing the 10 com men tar ies from dis tin guished mem bers of the HCI com mu nity, we were pleased to see that they had joined the de bate ...

Exposure of A549 human lung carcinoma cells to 10"8 M 12O-tetradecanoylphorbol-13-acetate (TPA) resulted in a change in cell morphology and caused the arrest of cell growth. After 4-5 days of exposure to TPA the cells started to proliferate again. However, on removal of the cells from the culture flask and reseeding, the cells had regained their sensitivity towards TPA. Cells which were subcult...

Human granulocyte colony-stimulating factor (G-CSF) rapidly loses the biological activity and the receptor binding capacity following radioiodination. We have made a mutein of human G-CSF, KW-2228, in which Thr-1, Leu-3, Gly-4, Pro-5, and Cys-I7 were respectively substi tuted with Ala, Thr, Tyr, Arg, and Ser; showed more potent G-CSF activity; and retained full biological activity and receptor ...

from such tumors. Only limited attempts have been made to evaluate tissues from other diseases that are associated with lymphoreticular proliferation. Results with acute phase, mononuclear cells from one case of infectious mononucleosis were negative, but this finding obviously needs confirma tion by study of additional cases. Carcinomas of various origins (e.g., lung, stomach, colon, rectum, o...

Many malignancies harbor mutated ras proto-oncogenes encoding 21 kDa proteins with single amino acid substitutions. Previous studies have shown that the aberrant p21 raJ proteins are potential tumor-specific antigens in that CD4'" class II major histocompatibIlity complex-restricted T cells spe· cific for the mutated segment of vanous oncogenic p21 raJ proteins can be elicited by immunization i...

The progression from normal breast epithelium to a malignant phenotype may depend on changes in genetic events as well as failure of host mechanisms. Intermediate biomarkers are needed to more effectively identify malignant progression as well as to develop the potential for more specific treatments and prevention strategies. The nuclear matrix is the RNA-protein network which forms the skeleto...

In this paper, we apply the theory of task technology fit to mobile technology, focusing specifi−cally on the role of user mobility. We describe the results of an empirical study of 216 business users of mobile devices that included various smart phones, personal digital assistants (PDAs), and laptop computers. Our findings suggest that (1) the relationship between task difficulty and functiona...

dictive value for subsequent compatibil¬ ity. In circumstances where the anti¬ body screen is positive, however, additional testing becomes necessary. The antibody expressed in the recipi¬ ent's serum must be characterized and the donor red blood cells tested for the presence of the corresponding antigen. The process of characterizing donor red blood cells as to their expression ofa particular ...