Introduction: Ascorbic acid (AA) is present in high concentrations with heterogeneous distribution in the mammalian brain. Previous studies have shown that release of various neurotransmitters such as glutamate, acetylcholine and dopamine might be involved in the central AA release. On the other hand all of these neurotransmitters and the region CA1 of the hippocampus are involved in learnin...

diabetes mellitus is accompanied with disturbances in learning, memory, and cognitive skills in the humans and experimental animals. due to the anti-diabetic and antioxidant activity of pelargonidin (pg), this research study was conducted to evaluate the efficacy of chronic oral pg on alleviating learning and memory disturbance in streptozotocin-diabetic rats. male wistar rats were divided into...

Objective(s) Diabetes mellitus is associated with disturbances of learning and memory and cognitive functioning. Aegle marmelos Corr. from Rutaceae family is widely used in Iranian folk medicine for the treatment of diabetes mellitus. Considering the beneficial antidiabetic and antioxidant potential of A. marmelos, this study was conducted to evaluate the effect of oral administration of A. ma...

background: cyclooxygenase (cox) enzyme known as a regulatory factor in synaptic plasticity. it has been reported that synaptic plasticity is one of the mechanisms involved in learning and memory processes. in the current study peripheral injection's effects of sodium salicylate (as a non selective cox inhibitor) on spatial learning and memory have been investigated. methods: four groups of mal...

Introduction: There are evidences showing the role of nitric oxide in the opiate reward properties. The role of nitric oxide signaling pathway as an intracellular mechanism on augmentation of long term potentiation in hippocampal CA1 area of rats is also confirmed. It has been also reported that oral morphine dependence facilitates formation of spatial learning and memory via activation of N...

objective(s) diabetes mellitus is associated with disturbances of learning and memory and cognitive functioning. aegle marmelos corr. from rutaceae family is widely used in iranian folk medicine for the treatment of diabetes mellitus. considering the beneficial antidiabetic and antioxidant potential of a. marmelos, this study was conducted to evaluate the effect of oral administration of a. mar...

hippocampus is essentially involved in learning and memory processes, and is known to be a target for androgen actions. the high density of the androgen receptors in hippocampus shows that there must be some relationship between androgens and memory. androgen effects on spatial memory are complex and contradictory. some evidence suggests a positive correlation between androgens and spatial memo...