PURPOSE The goal of this retrospective study is to review the causes of infantile spasms and to correlate aetiology with outcome. METHODS All children diagnosed with infantile spasms between 1990 and 2003 at our institution were included. Charts were reviewed for the presence or absence of a defined aetiology/association, response to treatment, long-term epileptic and cognitive outcome. RES...

objective infantile spasms (is) or west syndrome is a convulsive disease characterized by brief, symmetric axial muscle contractions (neck, trunk, and/or extremities).the therapy universally recognized as most effective in the treatment of is, is treatment with the adrenocorticotropic hormone (acth) or oral corticosteroids. this therapy however has important side effects. many studies have soug...

objective infantile spasms (is) is one of the catastrophic epileptic syndromes of infancy.the purpose of this study was to evaluate clinical efficacy and safety oftopiramate (tpm) as the first -line drug in the treatment of infantile spasms. materials and methods in a quasi- experimental study, efficacy and safety of tpm in rteatment of fortychildren with is who were referred to pediatric neuro...

how to cite this article: asadi-pooya aa, sharifzade m. west syndrome in south iran: electro-clinical manifestations. iran j child neurol. 2013 summer; 7(3): 40-44. objective we aimed to determine the clinical and electroencephalographic (eeg) characteristics of the patients with west syndrome (ws) in south iran. materials & methods in this retrospective study, all patients with a clinical diag...

how to cite this article:  fallah r, salor f, akhavan karbasi s, motaghipisheh h. randomised clinical efficacy trial of topiramate and nitrazepam in treatment of infantile spasms. iran j child neurol. 2014 winter; 8(1):12-19. objective infantile spasms (is) are among the most catastrophic epileptic syndromes of infancy. the purpose of this study was to compare efficacy and safety of topiramate ...

Mechanisms underlying coronary spasm are still poorly understood. The aim of the study was to assess the hypothesis that fluctuations in the development of coronary spasm might reflect inputs from the adjacent esophageal system. We enrolled patients admitted to the coronary care unit for episodes of nocturnal angina. Seven patients with variant angina and five with coronary artery disease (CAD)...

Mentalis muscle responses to electrical stimulation of the zygomatic branch of the facial nerve are considered abnormal muscle responses (AMRs) and can be used to monitor the success of decompression in microvascular decompression (MVD) surgery. The aim of this study was to compare the long-term outcome of MVD surgery in which the AMR disappeared to the outcome of surgery in which the AMR persi...

Holoprosencephaly is a category of congenital brain malformation that is frequently associated with epilepsy. Epileptic spasms and partial seizures are reported with a variety of electrographic ictal and interictal EEG findings. We report a case of severe alobar holoprosencephaly with cortical tissue limited to inferior-anterior-frontal areas and a thin mantle over the posterior areas, and no a...

Infantile Spasms is a rare disorder consisting of epileptic spasms that occur before the age of one year. This severe epilepsy affects about 0.31 in 1000 births with an average age at onset of 6 months. Treatment usually consists of hormonal therapies (adrenocorticotropic hormone or corticosteroids) or vigabatrin. Decisions about choice of therapy are complicated because these first-line treatm...