BACKGROUND The aqueous-methanolic extract of Amaranthus spinosus (A. spinosus Linn.,) whole plant, was studied for its laxative, spasmolytic and bronchodilator activities to validate some of its medicinal uses. METHODS The crude extract of A. spinosus was studied in-vivo for bronchodilator and laxative activities and in-vitro using isolated tissue preparations which were mounted in tissue bat...

The technique of polarised light goniometry was used to quantify objectively parameters of the spastic gait during a double-blind cross-over trial comparing the spasmolytic effects of DS103-282, baclofen and placebo. Only minimal objective and subjective changes in gait were found when the results of treatment with DS103-282 or baclofen were compared with those of treatment with placebo.

The binding sites of antitumor drug doxorubicin (DOX) and its analogue N-(trifluoroacetyl) doxorubicin (FDOX) with tRNA were located, using FTIR, CD, fluorescence spectroscopic methods and molecular modeling. Different binding sites are involved in drug-tRNA adducts with DOX located in the vicinity of A-29, A-31, A-38, C-25, C-27, C-28, G-30 and U-41, while FDOX bindings involved A-23, A-44, C-...

The mechanism by which racemic (R(+/-)) ketamine relaxes airway smooth muscle is unclear and there is no information on the differential effects of ketamine and its isomers. In this study, we have examined the spasmolytic effect of R(+/-) ketamine and its isomers S(+) and R(-) ketamine and the role of intracellular calcium and opioid receptors in R(+/-) ketamine-induced relaxation. The tension ...

Casuarina equisetifolia (Casuarinaceae) is considered a medicinal plant and is traditionally used for the treatment of diarrhoea. Preliminary phytochemical screening of methanolic extract of the aerial bark revealed the presence of carbohydrates, alkaloids, proteins, glycosides, saponins, flavonoids and tannins. The extract reduced contractions in isolated ileum induced by spasmogens like ACh, ...

o objective: many biological studies have been done to determine the activity of medicinal plants on gastrointestinal function. since acetylcholine is the major transmitter involved in the gastrointestinal motility and there are some evidences regarding the cholinergic modulatory effect of hops extract, in the present study spasmolytic and antispasmodic action of hops(humulus lupulus) on acetyl...

hydroalcoholic extract of pycnocycla spinosa has spasmolytic effect in vitro and antidiarrhoeal action in vivo . the aim of this research was to separate fractions of total hydroalcoholic extract of p. spinosa guided by their spasmolytic activity. aerial parts of p. spinosa were extracted with ethanol. the concentrated extract was subjected to column chromatography and thin layer chromatography...

Metamizole, a non-steroidal anti-inflammatory drug with weak anti-inflammatory and spasmolytic effects, is used as an analgesic and antipyretic agent. Many adverse reactions to metamizole, such as early or late-onset systemic reactions and bone marrow suppression, have been identified. In this report, we present a case of systemic reaction after the application of parenteral metamizole (Novalgi...