نتایج جستجو برای: soluplus
تعداد نتایج: 99 فیلتر نتایج به سال:
The objective of the present investigations was to assess use thermodynamic phase diagrams and Gibbs free energy mixing, ?Gmix, for screening polymeric carriers by determining ideal drug-loading an amorphous solid dispersion formulation optimum processing temperature hot-melt extrusion a non-glass-forming drug. Mefenamic acid (MFA) used as model drug four chemically distinct polymers with close...
In this study, we examine the relationship between the physical structure and dissolution behavior of olanzapine (OLZ) prepared via hot-melt extrusion in three polymers [polyvinylpyrrolidone (PVP) K30, polyvinylpyrrolidone-co-vinyl acetate (PVPVA) 6:4, and Soluplus® (SLP)]. In particular, we examine whether full amorphicity is necessary to achieve a favorable dissolution profile. Drug–polymer m...
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