The BMP pathway patterns the dorsal region of the Drosophila embryo. Using an antibody recognizing phosphorylated Mad (pMad), we followed signaling directly. In wild-type embryos, a biphasic activation pattern is observed. At the cellular blastoderm stage high pMad levels are detected only in the dorsal-most cell rows that give rise to amnioserosa. This accumulation of pMad requires the ligand ...

In the Drosophila embryo, formation of a bone morphogenetic protein (BMP) morphogen gradient requires transport of a heterodimer of the BMPs Decapentaplegic (Dpp) and Screw (Scw) in a protein shuttling complex. Although the core components of the shuttling complex--Short Gastrulation (Sog) and Twisted Gastrulation (Tsg)--have been identified, key aspects of this shuttling system remain mechanis...

This paper reports on a project to develop SOG (Synthetic Occupancy Generator), a system to create realistic, but synthetic residential occupancy (name and address) histories as input for Entity Resolution (ER) processes. ER processes are intended to link records referencing the same, or related, real-world entities. Most organizations use some type of ER process to recognize their customers or...

Vein differentiation is controlled by groups of genes that act in two developmentally distinct phases. During mid-third larval instar and early prepupal stages, the positions of vein territories are defined within the monolayer of wing imaginal disc cells (reviewed by Bier, 2000). In the second phase of vein development, during pupal stages, the vein versus intervein cell fate choice is resolve...