NAC1 is a transcriptional corepressor protein that is essential to sustain cancer cell proliferation andmigration. However, the underlying molecular mechanisms of NAC1 function in cancer cells remain unknown. In this study, we show that NAC1 functions as an actin monomer–binding protein. The conserved BTB protein interaction domain in NAC1 is theminimal region for actin binding. Disrupting NAC1...

Nucleus accumbens-1 (NAC1), a nuclear factor belonging to the bric-a-brac-tramtrack-broad complex/pox virus and zinc finger gene family, is known to serve important roles in the proliferation and growth of tumor cells, and in chemotherapy resistance. However, the underlying molecular mechanisms through which NAC1 contributes to drug resistance remain unclear. In the present study, the role of N...

The effects of sodium deprivation for 10 d, a period sufficient to induce sodium appetite, on gustatory nerve discharges in rats were determined. Chorda tympani responses to concentration series of sodium chloride, sucrose, hydrochloric acid, and quinine hydrochloride were recorded and analyzed without the experimenter knowing the animal's deprivation condition. After deprivation, both whole ne...

-The reaction of kaolin with NaC1 was followed by dynamic thermal analysis and mass spectrometry under/'42, CO2, and air atmospheres and in a 10-5-torr vacuum. The weight loss was a function of the atmosphere used and, according to mass spectrometry, was due to the evolution of H20, HC1, and very small amounts of H2. HC1 was formed only after the release of 85% of the hydroxyl content of the ka...

BACKGROUND Oral epithelial dysplasia (OED) and carcinoma in situ (CIS) are defined by dysplastic cells in the epithelium. Over a third of oral squamous cell carcinoma (OSCC) patients present with associated OED. However, accurate histopathological diagnosis of such lesions is difficult. Nucleus accumbens-associated protein 1 (NAC1) is a member of the Pox virus and Zinc finger/Bric-a-brac Tramtr...

I t was pointed out by Osterhout I that substances which increase the electrical conductivity of tissues are antagonized by those which decrease it. An illustration of this is seen in antagonism between NaC1 (which increases conductivity) and Na taurocholate ~ (which decreases it). This case has additional interest as an example of antagonism between anions as well as of antagonism between orga...

The purpose of this study was to investigate the role of NAC1 in the development of endometrial cancer. NAC1 expression and localization were assessed with immunohistochemistry in the normal cyclic human endometrium, hyperplastic endometrium, and endometrial cancer. Expression of NAC1 in the glandular cells was significantly higher in the early and mid proliferative phases than in the other men...

The present study has investigated the synthesis of copper nanoparticles via copper dismutation reaction in an aqueous solution and ambient conditions. Copper (II) chloride hydrate ( ), sodium oleate (SO), sodium chloride (NaCl) and ethylene diamine (EN) have been used as copper (I, II) ions source, surfactant, chloride ions supplier and ligand, respectively. Also, an amount of hydrochloric aci...

BACKGROUND Serum chloride levels were recently found to be independently associated with mortality in heart failure (HF). METHODS AND RESULTS We investigated the relationship between serum chloride and clinical outcomes in 7195 subjects with acute myocardial infarction complicated by reduced left ventricular function and HF. The studied outcomes were all-cause mortality, cardiovascular mortal...