OBJECTIVE Proton therapy can result in clinically significant radiation dermatitis. In some clinical scenarios, such as lung or breast cancer, the risk of severe radiation dermatitis may limit beam arrangement and prescription doses. Patients undergoing proton therapy for prostate cancer commonly develop mild radiation dermatitis. Herein, we report the outcomes of two prostate cancer patients w...

Skeletal anomalies in farmed fish are a relevant issue affecting animal welfare and health and causing significant economic losses. Here, a high-density genetic map of European seabass for QTL mapping of jaw deformity was constructed and a genome-wide association study (GWAS) was carried out on a total of 298 juveniles, 148 of which belonged to four full-sib families. Out of 298 fish, 107 were ...

Purpose The purpose of this work is to (a) demonstrate the feasibility delivering a spread-out Bragg peak (SOBP) proton beam in ultra-high dose rate (FLASH) using therapy synchrocyclotron as major step toward realizing an experimental platform for preclinical studies, and (b) evaluate response four models ionization chambers such radiation field. Methods A clinical Mevion HYPERSCAN® was adjuste...

Materials and methods: Cell culture: The HSG cells were grown in E-MEM (SIGMA) supplemented with 10% FBS and antibiotics under a humidified air with 5% CO2 at 37 ̊C. The cells were seeded into T25 cm 2 flask (CORNING) at a concentration of 4 × 10 cells per flask for 48 h prior to irradiation. Irradiation and treatment with DMSO: Carbon ions (C) were accelerated by the HIMAC synchrotron to 290 Me...

INTRODUCTION The range shifter (RS) is used to treat shallow tumors for a proton pencil beam scanning system (PBS). Adding RS certainly complicates the commissioning of the treatment planning system (TPS) because the spot sizes are significantly enlarged with RS. In this work, we present an efficient method to configure a commercial TPS for a PBS system with a fixed RS. METHODS By combining a...

The effect of carbon ion radiotherapy on hypoxic tumors has recently been questioned because of low linear energy transfer (LET) values in the spread-out Bragg peak (SOBP). The aim of this study was to investigate the role of hypoxia and local oxygenation changes (LOCs) in fractionated carbon ion radiotherapy. Three-dimensional tumors with hypoxic subvolumes were simulated assuming interfractio...

Background To investigate the potential molecular mechanism of ovarian cancer (OC) evolution and immunological correlation using integrated bioinformatics analysis. Methods Data from Gene Expression Omnibus was used to gain differentially expressed genes (DEGs). Ontology Kyoto Encyclopedia Genome pathway analysis were completed by utilizing Database for Annotation, Visualization, Integrated Dis...