نتایج جستجو برای: smarca4 gene
تعداد نتایج: 1141500 فیلتر نتایج به سال:
The SWI/SNF complex is an important regulator of gene expression that functions by interacting with a diverse array of cellular proteins. The catalytic subunits of SWI/SNF, BRG1 and BRM, are frequently lost alone or concomitantly in a range of different cancer types. This loss abrogates SWI/SNF complex function as well as the functions of proteins that are required for SWI/SNF function, such as...
Cancer genetic heterogeneity offers a wide repertoire of molecular determinants to be screened as therapeutic targets. Here, we identify potential anticancer targets by exploiting negative genetic interactions between genes with driver loss-of-function mutations (recessive cancer genes) and their functionally redundant paralogs. We identify recessive genes with additional copies and experimenta...
OBJECTIVES To investigate a shared genetic aetiology for skin involvement in psoriasis and psoriatic arthritis (PsA) by genotyping single-nucleotide polymorphisms (SNPs), reported to be associated in genome-wide association studies of psoriasis, in patients with PsA. METHODS SNPs with reported evidence for association with psoriasis were genotyped in a PsA case and control collection from the...
TOPIC: Lung Cancer TYPE: Medical Student/Resident Case Reports INTRODUCTION: SMARCA4 (SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily A, member 4) gene loss in non-small cell lung cancer (NSCLC) has been documented for the last 20 years but is only recently being recognized as a distinct NSCLC subset. Currently, there limited data on its morphologic descrip...
Chromatin structure and its changes or maintenance throughout developmental checkpoints play indispensable role in organismal homeostasis. Chromatin remodeling factors of the SWI/SNF2 superfamily use ATP hydrolysis to change DNA-protein contacts, and their loss-of-function or inappropriate increase leads to distinct human pathologic states. In this review, we focus on the translational view of ...
Epigenetic regulation, such as DNA methylation plays an important role in the control of imprinting. Lsh, a member of the SNF2 family of chromatin remodeling proteins, controls DNA methylation in mice. To investigate whether Lsh affects imprinting, we examined CpG methylation and allelic expression of individual genes in Lsh-deficient embryos. We report here that loss of Lsh specifically alters...
Introduction Burkitt lymphoma/leukemia (BL/BAL) is the most common lymphoma in children, and sporadic subtype dominant Chinese populations. MYC gene translocations are essential for BL/BAL (sBL/BAL), but other mutations also play important roles sBL/BAL. Material methods Clinical data of ten children with sBL/BAL were collected, next generation sequencing tumor tissues was carried out. Cases BL...
ABSTRACT During development, gene expression is tightly controlled to facilitate the generation of diverse cell types that form central nervous system. Brahma-related 1 (Brg1, also known as Smarca4) catalytic subunit SWItch/sucrose nonfermentable (SWI/SNF) chromatin remodeling complex regulates transcription. We investigated role Brg1 between embryonic day 6.5 (E6.5) and E14.5 in Sox2-positive ...
The activation of muscle-specific gene expression requires the coordinated action of muscle regulatory proteins and chromatin-remodeling enzymes. Microarray analysis performed in the presence or absence of a dominant-negative BRG1 ATPase demonstrated that approximately one-third of MyoD-induced genes were highly dependent on SWI/SNF enzymes. To understand the mechanism of activation, we perform...
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