Quantitative structure-activity relationships (QSARs) for prediction of the reaction rate constants of phenols and phenolates with three photochemically produced oxidants, singlet oxygen, carbonate radical, and triplet excited state sensitizers/organic matter, are developed. The predictive variable is the one-electron oxidation potential (E1), which is calculated for each species using density ...

Photodynamic therapy (PDT) has proved to be a viable and interesting alternative to currently used less selective methods for palliative care of cancer and, in a limited number of cases, for curative treatment. Still, in spite of impressive progress and a few approvals for clinical applications, the great potential of PDT has not yet been fully realized because of current defi ciencies of appli...

BACKGROUND Hair dye products constitute an important source of allergen exposure, and contribute importantly to allergic contact dermatitis in consumers and hairdressers. OBJECTIVES To evaluate the presence of potent contact sensitizers in oxidative hair dye products intended for home use on the US market. METHODS Ingredient labels of 107 hair dyes from 10 major brands were examined and use...

The development of non-animal methods for skin sensitization testing is an urgent challenge. Some of the most promising in vitro approaches are based on the analysis of phenotypical and functional modifications induced by sensitizers in dendritic cell models. In this work, we evaluated, for the first time, a fetal skin-derived dendritic cell line (FSDC) as a model to discriminate between sensit...

We have designed and synthesized a new symmetrical porphyrins 3a-d and their nanoparticles based on extended π-conjugation concept. The new sensitizers were fully characterized by CHN analysis, UV-Vis., H-NMR, TEM and Mass spectroscopy. The new sensitizers and their nanoparticles were evaluated as antitumor activity against HepG2, WI-38, VERO and MCF-7 cell lines. It was found that porphyrin na...

Cyclometalated ruthenium sensitizers have been synthesized that differ with number of thiophene units on the auxiliary ligands. Sensitizers possessing four (SA25, SA246, and SA285) or none (SA282) sulfur atoms in their structures, were tested in solar cell devices employing I3-/I- redox mediator, enabling an estimation of the influence of sulfur-iodine/iodide interactions on dye-sensitized sola...

Heart lipoamide dehydrogenase, liver alcohol dehydrogenase and egg-white lysozyme are photo-oxidized in the presence of various dye sensitizers. The photodynamic process is preceded by the binding between the enzyme and the sensitizers. Among the commonly used dyes, halogenated xanthines and thiazine are effective sensitizers for the photo-inactivation of these three enzymes. Histidine residues...

A series of Ru-(II) polypyridyl complexes, containing carboxylicand sulphonic ‘anchor’ groups, were synthesized as sensitizers for nanocrystalline TiO2. Depending on number and type of ligands the sensitizers are divided into three classes: tris-homoleptic complexes 1a–d, tris-heteroleptic complexes 2a–d and bis-complexes 3a–f. The compounds were characterized and the photophysical and electroc...

In vitro approaches to address key steps of chemical-induced skin sensitization have been developed, but there is uncertainty how keratinocytes, which play a crucial role not only regarding xenobiotic metabolism but also skin inflammation, impact on a chemical's potential and potency to activate dendritic cells. We investigated these aspects by coculturing THP-1 cells, as surrogate dendritic ce...