نتایج جستجو برای: skin permeability rate

تعداد نتایج: 1179169  

Objective(s):Drug delivery through the skin can transfer therapeutic levels of drugs for pharmacological effects. Analgesics such as NSAIDs have gastrointestinal side effects and topical dosage forms of these drugs are mainly preferred, especially for local pains. Meloxicam is one of NSAIDs with no topical form in the market. In this research, we attempted to quantify the skin permeation of a m...

Journal: :European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2015
Ryotaro Miki Yasuna Ichitsuka Takumi Yamada Soichiro Kimura Yuya Egawa Toshinobu Seki Kazuhiko Juni Hideo Ueda Yasunori Morimoto

We aimed to develop a high-throughput screening (HTS) system for preliminary predictions of human skin permeability by using an artificial membrane that can mimic the permeation behaviour of lipophilic and hydrophilic compounds across the human skin. In this study, we synthesized a copolymer containing poly(dimethylsiloxane) (PDMS) and poly(ethylene glycol) (PEG) 6000 and impregnated it onto a ...

2016
Shujun Xin Li Ye George Man Chengzhi Lv Peter M Elias Mao-Qiang Man

Cigarette smoking is associated with various cutaneous disorders with defective permeability. Yet, whether cigarette smoking influences epidermal permeability barrier function is largely unknown. Here, we measured skin biophysical properties, including permeability barrier homeostasis, stratum corneum (SC) integrity, SC hydration, skin surface pH, and skin melanin/erythema index, in cigarette s...

Journal: :International journal of pharmaceutics 2008
Jung-Hwan Park Jeong-Woo Lee Yeu-Chun Kim Mark R Prausnitz

Although the effects of long exposure (>>1s) to moderate temperatures (< or =100 degrees C) have been well characterized, recent studies suggest that shorter exposure (<1s) to higher temperatures (>100 degrees C) can dramatically increase skin permeability. Previous studies suggest that by keeping exposures short, thermal damage can be localized to the stratum corneum without damaging deeper ti...

Journal: :Chemical and Pharmaceutical Bulletin 1989

Journal: :Gitakan teghekagir 2021

Skin permeability of Sevan trout has been studied during 30 min in different solutions: distilled water, 70% ethanol, solution 0.125 M KCl. The was measured by methylene blue. It shown that the skin for this dye changes depending, on what these shreds were kept and side shred tightened from. also KCl ethanol result structural layers, particularly epidermis.

Journal: :Environmental toxicology and pharmacology 2010
Małgorzata Kupczewska-Dobecka Marek Jakubowski Sławomir Czerczak

Our objectives included calculating the permeability coefficient and dermal penetration rates (flux value) for 112 chemicals with occupational exposure limits (OELs) according to the LFER (linear free-energy relationship) model developed using published methods. We also attempted to assign skin notations based on each chemical's molecular structure. There are many studies available where formul...

2006
Seung Hun Lee Se Kyoo Jeong Sung Ku Ahn

Skin, as the outermost organ in the human body, continuously confronts the external environment and serves as a primary defense system. The protective functions of skin include UV-protection, anti-oxidant and antimicrobial functions. In addition to these protections, skin also acts as a sensory organ and the primary regulator of body temperature. Within these important functions, the epidermal ...

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