Desmosomes are cell adhesion junctions required for the normal development and maintenance of mammalian tissues and organs such as the skin, skin appendages, and the heart. The goal of this study was to investigate how desmocollins (DSCs), transmembrane components of desmosomes, are regulated at the transcriptional level. We hypothesized that differential expression of the Dsc2 and Dsc3 genes i...

  Participation in sport activities has become increasingly popular, as a result, more patients are referred 10 dermatologists for disorders caused by sport activities. During most forms of exercise, the skin and it's appendages are under constant assault by traumatic and other environmental factors that can cause injury. Physical activity also predispose s the skin to infection and can exacer...

Patterns form with the break of homogeneity and lead to the emergence of new structure or arrangement. There are different physiological and pathological mechanisms that lead to the formation of patterns. Here, we first introduce the basics of pattern formation and their possible biological basis. We then discuss different categories of skin patterns and their potential underlying molecular mec...

Dominant mutations in keratin genes can cause a number of inheritable skin disorders characterized by intraepidermal blistering, epidermal hyperkeratosis, or abnormalities in skin appendages, such as nail plate dystrophy and structural defects in hair. Allele-specific silencing of mutant keratins through RNA interference is a promising therapeutic approach for suppressing the expression of muta...

Mutant animals in the skin and hair have been used to identify important genes in biomedical research. We describe a new mutant rat, sparse and wavy hair (swh), that spontaneously arose in a colony of inbred WTC rats. The mutant phenotype was characterized by sparse and wavy hair, which was most prominent at age 3-4 weeks, and was inherited in an autosomal recessive manner. The swh/swh rats sho...

Dr. Montagna has made many contributions to our knowledge of the microscopic anatomy of the skin and its appendages. In this book he has tried to close the gap which so often separates structure and function. And he has succeeded in this endeavor. The book is directed to persons interested in the biology of skin. It is divided into the following eight sections: The general anatomy of skin, the ...

Dr. Montagna has made many contributions to our knowledge of the microscopic anatomy of the skin and its appendages. In this book he has tried to close the gap which so often separates structure and function. And he has succeeded in this endeavor. The book is directed to persons interested in the biology of skin. It is divided into the following eight sections: The general anatomy of skin, the ...

Introduction: Superficial mycoses refer to the diseases of skin and its appendages caused by fungi. Aims & Objectives: The present study was undertaken to find out the prevalence of different clinical types of Dermatomycoses including Dermatophytes, candida spp. and dermatomycotic mold infections of skin and its appendages and their etiological agents in and around Aligarh region of Northern In...

The type I keratin 17 (K17) shows a peculiar localization in human epithelial appendages including hair follicles, which undergo a growth cycle throughout adult life. Additionally K17 is induced, along with K6 and K16, early after acute injury to human skin. To gain further insights into its potential function(s), we cloned the mouse K17 gene and investigated its expression during skin developm...