نتایج جستجو برای: siv
تعداد نتایج: 3091 فیلتر نتایج به سال:
CD4+ T lymphocyte subsets are targeted to different degrees by SIV infection. We studied central memory, effector memory, naïve, and regulatory T cell levels longitudinally in 11 SIV(mac251)-infected pigtail macaques. Depletion of CD28+CD95+ central memory CD4+ T cells, but not other populations, correlated with both SIV viral load and disease progression. A low pre-infection level of central m...
OBJECTIVES Although antiretroviral therapy (ART) effectively suppresses HIV-1 replication, it does not eradicate the virus and ART interruption consistently results in rebound of viraemia, demonstrating the persistence of a long-lived viral reservoir. Several approaches aimed at reducing virus persistence are being developed, and accurate measurements of the latent reservoir (LR) are necessary ...
Human endogenous retrovirus type K (HERV-K) transcripts are upregulated in the plasma of HIV-infected individuals and have been considered as targets for an HIV vaccine. We evaluated cynomolgus macaque endogenous retrovirus (CyERV) mRNA expression by RT-qPCR in PBMCs isolated from a cohort of animals previously utilized in a live attenuated SIV vaccine trial. CyERV env transcript levels decreas...
In contrast to human immunodeficiency virus (HIV)-infected humans, natural hosts for simian immunodeficiency virus (SIV) very rarely progress to acquired immunodeficiency syndrome (AIDS). While the mechanisms underlying this disease resistance are still poorly understood, a consistent feature of natural SIV infection is the absence of the generalized immune activation associated with HIV infect...
There is an urgent need for human immunodeficiency virus (HIV) vaccines that induce robust mucosal immunity. Influenza A viruses (both H1N1 and H3N2) were engineered to express simian immunodeficiency virus (SIV) CD8 T-cell epitopes and evaluated following administration to the respiratory tracts of 11 pigtail macaques. Influenza virus was readily detected from respiratory tract secretions, alt...
We characterize a high-density sample of negatively charged silicon-vacancy (${\mathrm{SiV}}^{\ensuremath{-}}$) centers in diamond using collinear optical multidimensional coherent spectroscopy. By comparing the results complementary signal detection schemes, we identify hidden population ${\mathrm{SiV}}^{\ensuremath{-}}$ that is not typically observed photoluminescence and which exhibits signi...
Background: Reasons for acceptance of seasonal influenza vaccine (SIV) vaccination among pregnant women in China are poorly understood. We assessed the intention to accept SIV among pregnant women in Zhejiang province, by using a self-administrated structured questionnaire developed on the basis of health belief model (HBM). Methods: From 1 January to 31 March 2014, pregnant women with ≥12 gest...
As potential targets for human immunodeficiency virus type 1 and simian immunodeficiency virus (HIV-1 and SIV), dendritic cells (DCs) likely play a significant role in the onset and spread of infection as well as in the induction of antiviral immunity. Using the SIV-macaque system to study the very early events in DC-virus interactions, we compared chemically inactivated SIV having conformation...
The genomic sequences of HIV-1 isolates are closely related to the sequences of simian immunodeficiency viruses of chimpanzees SIV (cpz) [1]. It is widely presumed, therefore, that a SIV (cpz)-derived virus can evolve into HIV. The time at which humans initially became infected with SIV (cpz) or with a SIV (cpz)-derived virus is less certain. Yet this is clearly relevant to the likely mode of v...
SIV infection of nonhuman primates is widely utilized as a powerful model of human AIDS. The major effort in this field has so far been oriented towards the induction of an AIDS like disease in the disease susceptible species with the aim to elucidate mechanisms of HIV/SIV induced disease. The fact that there exist disease resistant natural SIV infected host species offers a unique opportunity ...
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