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تعداد نتایج: 46 فیلتر نتایج به سال:
BACKGROUND AIB1 (amplified in breast cancer I) is a member of the p160 steroid receptor coactivator family. AIB1 is frequently overexpressed in breast cancer and has functions that promote oncogenesis that are independent of estrogen receptor (ER) coactivation. We investigated prognostic significance of AIB1 and relationship between AIB1 and ER, progesterone receptor (PR), androgen receptor (AR...
chemotherapy. Metastatic or advanced cancers with limited effects of radiation and chemotherapy have been the challenging issue in recent cancer therapy. In this situation, the molecular target cancer therapy has been successfully accepted for various cancers. This type of therapy is to suppress the cell proliferation or induce apoptosis of cancer cells by targeting particular molecules which p...
LBA4001 Background: HER2 amplification is common in upper GI tract (UGIT) adenocarcinomas and inhibition improves clinical outcomes. Lapatinib ditosylate (L), a dual anti EGFR and anti HER2 tyrosine kinase inhibitor with preclinical activity against these cancers, was investigated in a phase III, randomized, double blind trial evaluating efficacy and safety in combination with CapeOx as first-l...
HER2 protein is a transmembrane tyrosine kinase receptor belonging to the HER family. HER2 is known to be involved in the pathogenesis of several human cancers and its overexpression and/or amplification, in the last three decades, has been robustly associated with poor prognosis in breast cancer, leading to the use of trastuzumab and other anti-HER2 targeted agents as the backbone of HER2-posi...
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