A novel optimal single machine replacement policy using a single as well as a two-stage decision making process is proposed based on the quality of items produced. In a stage of this policy, if the number of defective items in a sample of produced items is more than an upper threshold, the machine is replaced. However, the machine is not replaced if the number of defective items is less than ...

Abstract Sequencing costs currently prohibit the application of single-cell mRNA-seq to many biological and clinical analyses. Targeted mRNA-sequencing reduces sequencing by profiling reduced gene sets that capture information with a minimal number genes. Here we introduce an active learning method identifies but highly informative enable identification cell types, physiological states genetic ...

This paper works on the concept of flatness and its practical application for the design of an optimal transient controller in a synchronous machine. The feedback linearization scheme of interest requires the generation of a flat output from which the feedback control law can easily be designed. Thus the computation of the flat output for reduced order model of the synchronous machine with simp...

Keywords: Single-machine sequencing Weighted number of tardy jobs Due date assignment a b s t r a c t The single-machine due date assignment problem with the weighted number of tardy jobs objective, (the TWNTD problem), and its generalization with resource allocation decisions and controllable job processing times have been solved in O(n 4) time by formulating and solving a series of assignment...

The nature and pace of genome mutation is largely unknown. Standard methods to investigate DNA-mutation rely on arraying or sequencing DNA from a population of cells, hence the genetic composition of individual cells is lost and de novo mutation in cell(s) is concealed within the bulk signal. We developed methods based on (SNP-) arraying and next-generation sequencing of single-cell whole-genom...

this paper works on the concept of flatness and its practical application for the design of an optimal transient controller in a synchronous machine. the feedback linearization scheme of interest requires the generation of a flat output from which the feedback control law can easily be designed. thus the computation of the flat output for reduced order model of the synchronous machine with simp...

After the official opening of the meeting by Ian Jackson (MRC Human Genetics Unit, UK), John McPherson (Washington University, USA) gave his plenary lecture Mapping and sequencing the mouse genome. He started with a report on the status of 'the other genome' (human), stating that they now have y2.9 Gb of sequence, 1.75 Gb of which is 'finished' and 99% of which is aligned to the chromosomes. Ch...