This vignette explains the principle of linkage disequilibrium network analyses (LDna) using the R-package LDna. LDna uses network analyses to find clusters of loci in high linkage disequilibrium (LD) from population genomic data sets. In LD networks vertices represent loci and edges represent LD values above given thresholds. Starting from a high LD threshold value, only few loci will be conne...

This paper is concerned with the dynamical properties of deterministically modeled chemical reaction systems with mass-action kinetics. Such models are ubiquitously found in chemistry, population biology, and the burgeoning field of systems biology. A basic question, whose answer remains largely unknown, is the following: for which network structures do trajectories of mass-action systems remai...

It is demonstrated that surface vibrational spectroscopy can be used to probe local ordering of adsorbates and the nature of inter-adsorbate interactions through dynamical dipole coupling among neighboring adsorbates. Our studies show that for CO adsorbed on Cu(100), first and second nearest neighbor interactions are repulsive. This repulsion prevents the formation of long range ordered structu...

We used simulation to explore the impact of common data imperfections (i.e., missing parents, genotyping error, map error, and missing genotypes) upon the performance of multipoint and single point linkage analysis in the analyses of linkage data from pairs of siblings affected with an idealized complex trait. The performance of single point and multipoint linkage was similar under an unrealist...

5 Single Cluster Clustering 16 5.1 Clustering Approaches . . . . . . . . . . . . . . . . . . . . . . . . . . 16 5.1.1 De nition-based Clusters . . . . . . . . . . . . . . . . . . . . 16 5.1.2 Direct Algorithms . . . . . . . . . . . . . . . . . . . . . . . . 18 5.1.3 Optimal Clusters . . . . . . . . . . . . . . . . . . . . . . . . . 20 5.2 Single and Monotone Linkage Clusters . . . . . . . . . ....

BACKGROUND The Centre for Data Linkage (CDL) has been established to enable national and cross-jurisdictional health-related research in Australia. It has been funded through the Population Health Research Network (PHRN), a national initiative established under the National Collaborative Research Infrastructure Strategy (NCRIS). This paper describes the development of the processes and methodol...