in the present study, the effect of apamin (potassium channel blocker) on tolerance to cocaine-induced locomotor activity in mice has been investigated. locomotor activity was measured by locomotor activity meter, animax, type s (lkb, farrad). intraperitoneal (ip) injection of different doses of cocaine (2.5, 5, 10 and 15 mg/kg) produced dose-dependent locomotor activity in mice.animals were tr...

PURPOSE To report two patients with lamotrigine-induced forced normalization (FN). METHODS Evaluation of the patient files, EEG, and video-EEG records, with special reference to the parallel clinical and EEG changes before, during, and after FN. RESULTS This is the first documented report of lamotrigine-induced FN. The two epileptic patients (one of them was a 10-year-old girl) were success...

Single intravenous doses of 10, 20, 40, and 80 mg and repeated once daily intravenous doses of 10 and 20 mg omeprazole induced a powerful and long lasting inhibition of pentagastrin stimulated gastric acid secretion (PAO) in healthy male volunteers. Single intravenous doses of 10, 20, 40, and 80 mg omeprazole inhibited PAO by 30% (p less than 0.01), 45% (p less than 0.01), 61% (p less than 0.01...

3.1: Treatment of the initial episode of SSNS 3.1.1: We recommend that corticosteroid therapy (prednisone or prednisolone)* be given for at least 12 weeks. (1B) 3.1.1.1: We recommend that oral prednisone be administered as a single daily dose (1B) starting at 60 mg/m/d or 2 mg/kg/d to a maximum 60 mg/d. (1D) 3.1.1.2: We recommend that daily oral prednisone be given for 4–6 weeks (1C) followed b...

OBJECTIVE Vitamin D is essential for skeletal health and prolonged deficiency results in infantile rickets and adult osteomalacia. The aim of this study is to determine the vitamin D status in pregnancy and to evaluate the effects of daily and of single-dose vitamin D supplementation. DESIGN A prospective randomized study at St Mary's Hospital London. PATIENTS A total of 180 women (Indian A...

Background: Many cardiovascular diseases may require lifelong anticoagulation therapy. Warfarin is the most prescribed medication in this regard, however, it has serious side effects. Recently the new issue regarding to warfarin dosing is considered in which some single nucleotide polymorphisms (SNPs) affecting cytochrome P450 system can impact on warfarin metabolism and dosing. Methods: 230 c...