نتایج جستجو برای: simvastatin
تعداد نتایج: 13002 فیلتر نتایج به سال:
Background : Rebuilding and renovation of lost bone whether because of physiologic or pathologic factors was one of the surgeons’ motivations from the past. Statins are commonly prescribed cholesterol-lowering drugs however, it has recently been shown that they also have the beneficial side effect of enhancing bone matrix formation. As a result, this study evaluates the possible osteogenic ef...
Methods: Twenty-four rats were divided into 4 groups, according to the treatment received over the 13 days before and after ligature insertion around first lower molar in order to induce periodontal disease (PD): Ss (Simvastatin-Simvastatin); Sw (Simvastatin-Water); Ws (Water-Simvastatin) and Ww (Water-Water). Simvastatin was administered by gavage (35mg/Kg/day). After euthanasia, radiographic,...
Background and purpose: Venlafaxine is an antidepressant that belongs to the family of selective serotonin and norepinephrine reuptake inhibitor (SNRIs) drugs. Recent studies have indicated that prolonged use of antidepressants leads to a state where increased formation of reactive oxygen species (ROS) overwhelms body antioxidant protection and subsequently induces DNA damage, lipid peroxidatio...
The aim of study was to investigate the anti-proliferative and inflammatory effects atorvastatin, rosuvastatin, simvastatin in lung cancer. statins were investigated Vero, BEAS-2B, A549 cell lines. In addition expressions BAX, BCL-2, TNFα, IL-10, IL-6, protein levels IL-6 determined. Cell viability MDA also measured. While numbers groups with low doses found be approximately 1x106/mL, prolifera...
Purpose: To study the effect of simvastatin on behavioral performance in a rat model autism, and its hippocampal brain-derived BDNF-TrkB pathway.
 Methods: Twelve rats with valproic acid (VPA)-induced autism were randomly divided into group group, while six healthy served as normal control group. Rats received drug (5 mg/kg) via i.p. route, injected equivalent volume saline place simvastat...
INTRODUCTION Between 2010 and 2012, the US Food and Drug Administration and Health Canada issued warnings to healthcare professionals emphasizing the increased risk of muscle problems with high-dose simvastatin. OBJECTIVE To measure the impact of the Health Canada safety warning regarding dose-dependent adverse effects of simvastatin on prescribing of low, medium, and high doses of simvastati...
background adiponectin is an adipose tissue-derived protein with anti-inflammatory properties. statins are a class of cholesterol-lowering drugs, widely used for treatment of cardiovascular diseases. objectives in the current study, we aimed to assess the effects of simvastatin on serum levels of adiponectin in patients with dyslipidemia, recruited from ghaem hospital, mashhad, iran. materials ...
Pleurotus pulmonarius crude aqueous (CA) extract was previously reported to have therapeutic potential, thus its ability alleviate serum total cholesterol, vasodilation, and improve the aortic tissue structure in hypercholesterolemia rat model studied. Eight groups of Wistar-Kyoto rats were involved including normal (G1), (G2), treatment (G3 G5) prevention (G6 G8). Two doses CA; 0.5 g/kg body w...
Introduction & Objective: Comparative reductase inhibitors, such as simvastatin increase HDL-cholestrol and decrease serum triglyceride and cholesterol. It is widely recognized that statins have organ protective nature and most effective for organ damage progressing. Obstructive uropathy can be used to indicate any obstruction to urinary flow which causes a developing of hydronephrosis, tubul...
BACKGROUND Simvastatin is classified as a Biopharmaceutics Classification System (BCS) Class-II compound with a poor aqueous solubility and an acceptable permeability through biomembranes. The strategy of increasing the in vitro dissolution has the potential to enhance the oral bioavailability when using nanosized crystalline drugs. OBJECTIVE The aim of this article was to prepare simvastatin...
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