A convenient and practical pathway to versatile silylated amides anilides is described via efficient selective ruthenium(ii) catalyzed ortho C–H silylation with different alkenes as the hydrogen acceptors.

Benzylic C-H lithiation of 3,4-benzothiophane and subsequent treatment with triphenyl- or trimethylchlorosilane under a variety of conditions leads to α,α- rather than α,α'-bis-silylation products as a consequence of anion stabilization by R3Si and very fast deprotonation of the intermediate monosilylated product, even with a sterically bulky base such as lithium diisopropylamide.

Aromatic C-H silylation of neat arenes with 1-hydrosilatrane was found to be efficiently catalyzed by iridium catalysts composed of 1/2[Ir(OMe)(cod)]2 and 2,9-dimethyl-1,10-phenanthroline at 120 °C to afford the corresponding silylated products in high yields. The silylated products can be used for the Hiyama cross-coupling reaction.

Asymmetric Catalysis An enantioselective intermolecular C−H silylation of heteroarenes for the synthesis acyclic Si-stereogenic silanes is reported by Chuan He et al. in their Communication (e202117820).

Abstract We report a Brønsted acid catalyzed enantioselective silylation of biaryl diols with an allylsilane as silicon source. This process enables facile access to enantioenriched silyl ethers axial stereogenicity. A control experiment supports mechanism proceeding by desymmetrization followed kinetic resolution.

We wish to report a simple synthetic procedure, which permits the regiospecific mono-acylation, alkylation and silylation at the 2-position of allyl 4,6-O-benzylidene alpha-D-glucopyranoside in high yields and which does not require the use of catalysts.