OBJECTIVE To assess the prevalence and clinical predictors of silent myocardial ischemia in asymptomatic patients with type 2 diabetes and to test the effectiveness of current American Diabetes Association screening guidelines. RESEARCH DESIGN AND METHODS In the Detection of Ischemia in Asymptomatic Diabetics (DIAD) study, 1,123 patients with type 2 diabetes, aged 50-75 years, with no known o...

BackgroundCoronary artery disease is the primary cause of death in patients with carotid and silent ischemia a marker for adverse coronary events. A new noninvasive cardiac diagnostic test, computed tomography-derived fractional flow reserve (FFRCT) can reliably identify ischemia-producing stenosis help to select revascularization. The purpose this study determine prevalence undergoing endarter...

OBJECTIVES The purpose of this study was to evaluate benzodiazepine receptor expression on leukocytes from patients with symptomatic or silent myocardial ischemia. BACKGROUND Silent myocardial ischemia is frequently observed in patients with coronary artery disease. Pain can be effectively controlled by various endogenous mechanisms. Benzodiazepines and their receptors play key roles in pain,...

Background/Aim. Ischemic heart disease is the major cause of morbidity and mortality in the world as well as in our country. Ischemic heart disease has the multifactorial origin and the presence of several risk factors increases the risk of myocardial ischemia. The aim of the study was to evaluate the frequency and characteristics of myocardial ischemia in asymptomatic subjects with two or more...

Type 2 diabetes mellitus (DM) has got a distinct association with coronary artery disease (CAD); and diabetic patients have 2-4 fold higher risk of developing CAD than people without DM [1]. However, progressive coronary artery disease remains asymptomatic in many cases of type 2 diabetes and this makes diagnosis difficult at proper time [2]. Routine screening of type 2 diabetics for asymptomat...

The role of myocardial oxygen demand in the genesis of silent myocardial ischemia was evaluated by measuring the heart rate and blood pressure changes preceding the silent ischemic events during daily life in 25 men with proven coronary artery disease. Simultaneous 24-48-hour ambulatory electrocardiographic and blood pressure monitoring were performed during unrestricted daily activities. Of th...

Silent focal ischemic mini infarcts in the brain are thought to cause no clinically overt symptoms. Some populations of hippocampal cells are particularly sensitive to ischemic events, however, rendering hippocampal functions especially vulnerable to ischemia-induced deficits. The present study investigated whether an otherwise silent ischemic mini infarct in the hippocampus (HPC) can produce i...