نتایج جستجو برای: signaling pathways
تعداد نتایج: 469190 فیلتر نتایج به سال:
Background and Aims: Hepatitis C virus (HCV) infection is an important risk factor for the development of liver cancer. The HCV NS3 protein plays a key role in the virus life cycle and can affect normal cellular activities, such as cell proliferation, cell death, and cell signaling pathways. Moreover, it may influence malignancy development. Two cellular genes, heat shock protein 70 (HSP70) and...
Metastasis means the dissemination of the cancer cells from one organ to another which is not directly connected to the primary site. Metastasis has a crucial role in the prognosis of cancer patients. A few theories, different types of cell and several molecular pathways have been proposed to explain the mechanism of metastasis. In this work, the related articles in the limited period of time, ...
Abstract It was shown that several pathogenic bacterial effector proteins contain the Glu-Pro-Ile-Tyr-Ala (EPIYA) or a similar sequence. These bacterial EPIYA effectors are delivered into host cell via type III or IV secretion system, where they undergo tyrosine phosphorylation at the EPIYA sequences, which triggers interaction with multiple host cell SH2 domain-containing proteins and thereby...
Primordial Germ Cells (PGCs) are unipotent precursors of the gametes. PGCs can give rise to a type of pluripotent stem cells in vitro that are called embryonic germ (EG) cells. PGCs can also acquire such pluripotency in vivo and generate teratomas. Under specific culture conditions, PGCs can be reprogrammed to embryonic germ cells which are capable of expression of key pluripotency marker...
Background & Aims : Cancer cells proliferation may be mediated by abnormal phosphorylation of signaling pathways downstream of tyrosine kinase receptors such as Platelet derived growth factor receptor α (PDGFR-α) and β (PDGFR-β). We aimed to study the phosphorylation level of PDGFR-α and PDGFR-β and apoptosis in mouse normal leydig cells being exposed to Imatinib. Materials & Methods : The ...
Objective(s):Intermittent hypoxia (IH), caused by obstructive sleep apnea (OSA), could cause hippocampus or neuron damage through multiple signaling pathways, while the underlying mechanisms are still unclear. Thus, the present study aimed to explore the effect of IH on the biological functions of microglia cells. Materials and Methods:Cell proliferation of BV2 cells after exposure to IH were o...
objective(s): study of non-coding rnas is considerable to elucidate principal biological questions or design new therapeutic strategies. mirnas are a group of non-coding rnas that their functions in pi3k/akt signaling and apoptosis pathways after t cell activation is not entirely clear. herein, mirnas expression and their putative targets in the mentioned pathways were studied in the activated ...
toll-like receptor 4 (tlr4), considered one of the most important tlr, recognizes lipopolysaccharide of gram-negative bacteria. recognition of ligands by tlrs induces signaling pathways resulting in activation of transcriptional factors such as nf-κb which are involved in the expression of inflammatory cytokines and chemokines. to prevent an inappropriate immune response, a complex ...
objective: creb1 is an important downstream protein for many signaling pathways. by designing efficient sirnas against creb1, it may be possible to assess the role of molecules involved in signaling pathways in different cell types. in this research the efficiency of creb1 knockdown by two different sirnas in k562 cells has been studied. materials and methods: sirnas have been designed accordi...
signaling pathways are not isolated from their surroundings. they are also intervened by other signaling pathways known as “crosstalk mechanism”. one of the most important crosstalk mechanisms is the insulinegf network. although insulin and epidermal growth factor (egf) networks have some complexity in their isolated forms, their complexities will grow in the crosstalk network. in this study, w...
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