نتایج جستجو برای: signal regulatory proteins sirp
تعداد نتایج: 1068020 فیلتر نتایج به سال:
In PNAS, an article by Tseng et al. continues to examine an important and unique therapeutic manipulation that controls the growth of tumor cells in mice (1). This manipulation consists of using a monoclonal antibody specific to the membrane protein CD47 to block its biological activity: blocking CD47 reduces tumor growth by enabling macrophages to phagocytose the cancer cells (2–4). In this st...
Background and purpose: Interferon beta-1b recombinant protein is used for reducing the relapse rate and treatment in patients with Multiple sclerosis (MS). In this study, phylogenetic and in silico analysis of interferon beta-1b were conducted by servers and bioinformatics tools to predict its structural potential. Materials and methods: Physiological and physico-chemical characteristics of...
PU.1 is a key transcription factor for hematopoiesis and the reduction of this protein expression plays important roles in various hematological malignancies. To identify PU.1 downstream target genes, we recently reported dual microarray analyses, using PU.1 knockdown K562 (K562PU.1KD) cells stably expressing short inhibitory RNAs versus control c...
background: in the recent years, there has been an increasing interest in secretory production of recombinant proteins, due to its various advantages compared with intracellular expression. signal peptides play a critical role in prosperous secretion of recombinant proteins. accordingly, different signal peptides have been assessed for their ability to produce secretory proteins by trial-and-er...
In this paper, we study the adaptive version of the asymptotical Bayesian Optimum Radar Detector (BORD) built with a covariance matrix estimate. We investigate its properties, when the noise is modelled as a non-Gaussian complex process, such as Spherically Invariant Random Process (SIRP). We derive, for appropriate covariance matrix estimates, the analytical expression of the relationship betw...
Multiple-input multiple-output (MIMO) radar has become a thriving subject of research during the past decades. In the MIMO radar context, it is sometimes more accurate to model the radar clutter as a nonGaussian process, more specifically, by using the spherically invariant random process (SIRP) model. In this paper, we focus on the estimation and performance analysis of the angular spacing bet...
Signal regulatory proteins of the alpha subtype (SIRPalpha) are ubiquitous molecules of the immunoglobulin superfamily that negatively regulate protein tyrosine kinase receptor-dependent cell proliferation. Their intracytoplasmic domain contains four motifs that resemble immunoreceptor tyrosine-based inhibition motifs (ITIMs) and that, when tyrosyl-phosphorylated, recruit cytoplasmic SH2 domain...
Correlations of cognitive functioning with brain activation during a sternberg item recognition paradigm (SIRP) were investigated in patients with schizophrenia and in healthy controls studied at 8 sites. To measure memory scanning times, 4 response time models were fit to SIRP data. The best fitting model assumed exhaustive serial memory scanning followed by self-terminating memory search and ...
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