Article: Neves De Faria, Rita Isabel orcid.org/0000-0003-3410-1435, Soares, Marta Ferreira Oliveira orcid.org/0000-0003-1579-8513, Spackman, David Eldon orcid.org/0000-0001-8558-5973 et al. (5 more authors) (2017) Optimising the diagnosis of prostate cancer in the era of multi-parametric magnetic resonance imaging: a cost-effectiveness analysis based on the PROMIS study : How to optimise the di...

The sigma-1 receptor (Sig-1R) is an endoplasmic reticulum membrane protein that involves a wide range of physiological functions. The Sig-1R has been shown to bind psychostimulants including cocaine and methamphetamine (METH) and thus has been implicated in the actions of those psychostimulants. For example, it has been demonstrated that the Sig-1R antagonists mitigate certain behavioral and ce...

aBooth School of Business, University of Chicago, Chicago, Illinois 60637; bNational Bureau of Economic Research, Cambridge, Massachusetts 02138; cBusiness School, Sichuan University, 610000 Chengdu, China; dFox School of Business, Temple University, Philadelphia, Pennsylvania 19122 ∗Corresponding author Contact: [email protected], http://orcid.org/0000-0002-6488-9158 (J-PD); 149281891@qq....

Sigma-1 receptors (Sig-1Rs) are endoplasmic reticulum (ER)-resident proteins known to be involved in learning and memory. Dendritic spines in hippocampal neurons play important roles in neuroplasticity and learning and memory. This study tested the hypothesis that Sig-1Rs might regulate denritic spine formation in hippocampal neurons and examined potential mechanisms therein. In rat hippocampal...

Neurite outgrowth is one of the essential processes underlying development and plasticity of the nervous system. Enhancing neurite outgrowth, along with neural protection, is one of the most prominent therapeutic strategies against neuronal degeneration or damage. The sigma-1 receptor (Sig-1R) is a brain-enriched a receptor chaperone expressed in the ER membrane. As Sig-1R is involved in the mo...

One theory concerning the action of antidepressants relates to the drugs’ ability to induce an adaptive plasticity in neurons such as neurite sprouting. Certain antidepressants are known to bind to -1 receptors (Sig-1R) with high affinity. Sig-1R are dynamic endoplasmic reticulum proteins that are highly concentrated at the tip of growth cones in cultured cells. We therefore tested the hypothes...

Sigma-1 receptor (Sig-1R) is an intracellular chaperone protein with many ligands, located at the endoplasmic reticulum (ER). Binding of cocaine to Sig-1R has previously been found to modulate endothelial functions. In the present study, we show that cocaine dramatically inhibits store-operated Ca(2+) entry (SOCE), a Ca(2+) influx mechanism promoted by depletion of intracellular Ca(2+) stores, ...

This work is part of the TOUCH-HapSys project financially supported by the 5th Framework IST Program of the European Union, action line IST-2002-6.1.1., contract number IST-2002-38040. For the content of this paper the authors are solely responsible for, it does not necessarily represent the opinion of the European Community. Authors' addresses: Knut Drewing (corresponding author) is now at the...

sig Key {} sig Special, Regular extends Key {} one sig Control, Shift, Option, Command extends Special {} sig KeyPress {keys: set Key, event: Event} {one keys & Regular} sig Event {} fact {setObject (KeyPress, keys)} Note the use of Singleton to model the special keys. A prison database system tracks pairs of inmates who must not be placed in the same cell (because they belong to opposing gangs...